中国中药杂志

2021, v.46(04) 966-971

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基于外观性状和内在成分的黄芪药材质量等级评价
Evaluation of Astragali Radix quality grade based on appearance characteristics and internal ingredients

孙秀蕊;魏桂杰;王宏雅;赵雯雯;张哲;张婷;魏锋;张玉杰;
SUN Xiu-rui;WEI Gui-jie;WANG Hong-ya;ZHAO Wen-wen;ZHANG Zhe;ZHANG Ting;WEI Feng;ZHANG Yu-jie;School of Chinese Materia Medica,Beijing University of Chinese Medicine;Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institute for Food and Drug Control;

摘要(Abstract):

考察黄芪药材外观性状及内在成分的差异,为制定黄芪药材的质量等级评价体系提供依据。测定18批黄芪药材直径、醇(水)浸出物、7种黄酮类成分的含量,计算黄酮类成分苷元与苷的峰面积比,综合各项指标,进行主成分分析(PCA)和聚类分析(CA)。PCA和CA结果表明黄芪药材明显聚为3类,其中醇浸出物、芒柄花素/刺芒柄花苷、(毛蕊异黄酮+黄芪黄酮苷A)/毛蕊异黄酮葡萄糖苷是3种黄芪药材自变量投影重要性指标(VIP)差异最大的组分。表明将直径、醇(水)浸出物、黄酮类成分苷元与苷的峰面积比结合起来,并结合化学计量学方法对药材质量进行相关性分析,可为黄芪药材的等级评价体系的建立提供分析方法。
This study is to provide the basis of establishing a quality evaluation system, based on the differences in appearance and internal components of Astragali Radix from different sources. The diameter of 18 batches of Astragali Radix, the content of alcohol(water) extract and 7 kinds of flavonoids were determined. The peak area ratio of flavonoid aglycon to aglycone was calculated. PCA and CA were carried out by synthesizing various indexes. The results of PCA and CA showed that Astragali Radix was obviously clustered into three types. Alcohol extract, formononetin/formosan glycosides,(pilose isoflavones+astragalus flavonoid A)/pilose isoflavone glucoside are the most significant differences in the variable importance projection index(VIP) of Astragali Radix. Combining the diameter, alcohol(water) extract, flavonoid aglycon to aglycone peak area ratio can provide an analysis method for the establishment of the grade evaluation system of Astragali Radix.

关键词(KeyWords): 黄芪;等级评价;醇(水)浸出物;黄酮类;苷元与苷峰面积比;主成分分析;聚类分析
Astragali Radix;grade evaluation;alcohol(water) soluble extract;flavonoids;peak area ratio of aglycone to glycoside;principal component analysis;cluster analysis

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作者(Author): 孙秀蕊;魏桂杰;王宏雅;赵雯雯;张哲;张婷;魏锋;张玉杰;
SUN Xiu-rui;WEI Gui-jie;WANG Hong-ya;ZHAO Wen-wen;ZHANG Zhe;ZHANG Ting;WEI Feng;ZHANG Yu-jie;School of Chinese Materia Medica,Beijing University of Chinese Medicine;Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institute for Food and Drug Control;

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DOI: 10.19540/j.cnki.cjcmm.20200628.201

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