中国中药杂志

2019, v.44(10) 2090-2095

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海洋放线菌Streptomyces sp.MDW-06中1个新的聚酮类化合物
A new polyketide from marine-derived Streptomyces sp.MDW-06

王聪;邱子言;雷福厚;谭学才;姜明国;李浩;李小燕;
WANG Cong;QIU Zi-yan;LEI Fu-hou;TAN Xue-cai;JIANG Ming-guo;LI Hao;LI Xiao-yan;Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources,School of Marine Sciences and Biotechnology,Guangxi University for Nationalities;Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,School of Chemistry and Chemical Engineering,Guangxi Universi

摘要(Abstract):

分离鉴定海洋放线菌Streptomyces sp.MDW-06的次级代谢产物。利用柱色谱等方法对发酵产物进行分离、纯化,运用质谱、核磁共振和比旋光等手段鉴定化合物的结构,采用药敏纸片法和DPPH法评价了化合物的抗菌活性和抗氧化活性。从海洋放线菌Streptomyces sp.MDW-06的发酵产物中分离鉴定了6个化合物(1~6):streptopentanoic acid(1),germicidin A(2),germicidin B(3),isogermicidin A(4),isogermicidin B(5)以及oxohygrolidin(6)。其中化合物1为新化合物。化合物1在100 mg·L~(-1)下显示有弱的DPPH自由基清除活性,清除率为36. 4%。
To isolate and identify secondary metabolites of marine-derived Streptomyces sp.MDW-06,the isolations and purifications of compounds were performed by means of column chromatography over silica gel. And their structures were elucidated through the spectroscopic analysis of MS,NMR and specific rotations. The bioactivities were assayed by paper diffusion and DPPH method. From the fermentation broth of marine-derived Streptomyces sp.MDW-06,five compounds( 1-5) were isolated and identified as streptopentanoic acid( 1),germicidin A( 2),germicidin B( 3),isogermicidin A( 4),isogermicidin B( 5) and oxohygrolidin( 6),respectively. Compound 1 is a new compound. Compound 1 shows DPPH radical scavenging activity with 36. 4% at 100 mg·L~(-1).

关键词(KeyWords): 海洋放线菌Streptomyces sp.MDW-06;链霉菌;次生代谢产物
marine-derived Streptomyces sp;MDW-06;Streptomyces;secondary metabolite

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基金项目(Foundation): 2018年广西高校中青年教师基础能力提升项目(2018KY0177);; 广西民族大学青年基金项目(2018MDQN003);; 广西科技重大专项(桂科AA18242026);; 广西民族大学引进人才科研启动项目(2017KJQD004);; 广西自然科学基金项目(2017GXNSFBA198013);; 广西科技基地和人才专项(桂科AD18126005);; 广西创新驱动发展重大专项子课题(桂科AA17204087--21)

作者(Author): 王聪;邱子言;雷福厚;谭学才;姜明国;李浩;李小燕;
WANG Cong;QIU Zi-yan;LEI Fu-hou;TAN Xue-cai;JIANG Ming-guo;LI Hao;LI Xiao-yan;Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources,School of Marine Sciences and Biotechnology,Guangxi University for Nationalities;Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,School of Chemistry and Chemical Engineering,Guangxi Universi

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