中国中药杂志

2022, v.47(18) 4846-4853

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中药熊胆功效演进及成分研究概述
Efficacy evolution of bear bile and related research on components

李新月;苏芳芳;蒋超;张卫;王枫;朱青;杨光;
LI Xin-yue;SU Fang-fang;JIANG Chao;ZHANG Wei;WANG Feng;ZHU Qing;YANG Guang;College of Pharmacy, Hebei University of Chinese Medicine;China Academy of Chinese Medical Sciences;Chongqing Kingbear Biotechnology Co., Ltd.;

摘要(Abstract):

动物药为中医药的重要组成部分。熊胆为我国珍稀动物药材之一,具有清肝利胆、平肝镇惊、清热解毒等功效。晋至唐时期熊胆多应用于内外科和儿科的有限病证。目前熊胆已用于治疗儿科、妇科、内科、外科的多种疾病。熊胆化学成分及药理作用研究多集中于胆汁酸类成分,非胆汁酸类成分也具有一定的药理作用,但缺少相关研究来探讨其作用机制。熊胆来源动物现已被列为国家二级保护动物,通过生物转化途径得到转化熊胆粉有望在一定程度上缓解熊胆资源短缺的现状。熊胆替代品的相关研究保护了熊胆的来源动物,但存在功能量化、现代化诠释等方面的问题,需结合现代相关研究,梳理古籍中记载的熊胆功能主治。该文通过分析熊胆历代功能主治的发展及演进,系统整理熊胆的化学成分,梳理古籍中熊胆功效与临床应用的相关记载并关联熊胆现代相关药理作用与临床应用,总结熊胆安全性的研究进展,有利于熊胆现代功效明晰及功能量化,对熊胆的现代化诠释作一定的尝试性探索。
Animal medicine is an important part of traditional Chinese medicine(TCM). Bear bile is one of the rare animal-derived medicinal materials with the functions of clearing the liver, promoting bile secretion, calming the liver, relieving convulsions, clearing heat, and removing toxins. From the Jin Dynasty to the Tang Dynasty, bear bile was mainly used to treat internal diseases, surgical diseases, and pediatric diseases with limitations. At present, bear bile has been used to treat various diseases in pediatrics, gynecology, internal medicine, and surgery. Studies on the chemical constituents and pharmacological effects of bear bile mostly focused on bile acids. Although the non-bile acids also showed certain pharmacological effects, their mechanism of action was less investigated. At present, the source animals of bear bile are national second-class protected animals. Obtaining transformed bear bile powder through biotransformation is expected to alleviate the shortage of bear bile resources to a certain extent. Although related research on bear bile substitutes has protected bear bile resources, there are problems in functional quantification and modern interpretation. It is necessary to sort out the functions and indications of bear bile recorded in ancient books according to related modern research. This study firstly reviewed the evolution of bear bile functions and indications, analyzed the chemical components of bear bile, sorted out the relevant records of the efficacy and clinical application of bear bile in ancient books, and summarized the research progress in the safety of bear bile based on the modern pharmacological effects and clinical applications of bear bile, which is conducive to the clarification of modern efficacy and functional quantification of bear bile and the tentative exploration of the modern interpretation of bear bile.

关键词(KeyWords): 熊胆;功效主治;化学成分;药理作用;转化熊胆粉
bear bile;efficacy and indications;chemical composition;pharmacological action;transformed bear bile powder

Abstract:

Keywords:

基金项目(Foundation): 中国中医科学院科技创新工程项目(CI2021A03907,CI2021A03908)

作者(Authors): 李新月;苏芳芳;蒋超;张卫;王枫;朱青;杨光;
LI Xin-yue;SU Fang-fang;JIANG Chao;ZHANG Wei;WANG Feng;ZHU Qing;YANG Guang;College of Pharmacy, Hebei University of Chinese Medicine;China Academy of Chinese Medical Sciences;Chongqing Kingbear Biotechnology Co., Ltd.;

DOI: 10.19540/j.cnki.cjcmm.20220527.601

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