中国中药杂志

2021, v.46(18) 4654-4665

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芦丁衍生物的研究进展
Research progress on rutin derivatives

毛雅君;冯亚莉;王梦娇;吕志远;翟广玉;
MAO Ya-jun;FENG Ya-li;WANG Meng-jiao;LYU Zhi-yuan;ZHAI Guang-yu;School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology;

摘要(Abstract):

从天然产物中获得的化合物,应用于防病治病,效果更好。利用植物中的化学物质促进健康,是目前人们关注的热点。芦丁是一个典型的类黄酮,主要存在于日常食用的各种蔬菜、水果和中草药中。芦丁是天然的抗氧化剂,具有广泛的药理活性,如抗炎、抗病毒、抗肿瘤、预防和治疗心脑血管疾病等作用。由于生物利用度低、水溶性差,限制了在临床上的应用。芦丁的结构通过优化修饰,获得了溶解性好、生物利用度高、代谢稳定和毒副作用小的芦丁衍生物。最近几年来,已经合成了大量芦丁醚类、酯类、配合物等,并进行了活性检测。该文综述了近年来对芦丁的结构修饰,获得的性能优良,生物活性显著的衍生物。
Compounds derived from natural products present satisfactory efficacy in disease prevention and treatment. The use of chemical substances in plants to promote healthhas increasingly attracted people′s attention. Rutin, a typical flavonoid, is mainly found in various vegetables, fruits and Chinese herbal medicines. As a natural antioxidant, it features many pharmacological activities, such as anti-inflammation, anti-virus, anti-tumor, and prevention and treatment of cardiovascular and cerebrovascular diseases. However, the low bioavailability and poor water solubility limit its clinical application. In view of this, its structure is optimized and modified to afford rutin derivatives with good solubility, high bioavailability, stable metabolism and small toxic side effects. So far, a large number of rutin ethers, esters, and complexes have been synthesized and undergone activity testing. This paper reviews the structural modification of rutin in recent years, and the obtained derivatives have excellent properties and significant biological activity.

关键词(KeyWords): 芦丁;修饰;衍生物;醚;酯;配合物;生物活性
rutin;modification;derivative;ether;ester;complex;biological activity

Abstract:

Keywords:

基金项目(Foundation): 郑州市高等学校名师技术技能工作室项目(郑教高[2015]70号);; 河南省高等学校重点科研项目(21B350003)

作者(Authors): 毛雅君;冯亚莉;王梦娇;吕志远;翟广玉;
MAO Ya-jun;FENG Ya-li;WANG Meng-jiao;LYU Zhi-yuan;ZHAI Guang-yu;School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology;

DOI: 10.19540/j.cnki.cjcmm.20210429.602

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