中国中药杂志

2007, (06) 484-487

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α-细辛醚储库型贴片研究
Study on α-asarone reservoir-type patch

吴争;高建青;陈海靓;胡英;梁文权;
WU Zheng1,GAO Jian-qing1,CHEN Hai-liang1,HU Ying1,2,LIANG Wen-quan(1.Institute of pharmaceutics,Zhe jiang University,Hangzhou 310058,China;2.Zhejiang Pharmaceutical College,Ningbo 315100,China)

摘要(Abstract):

目的:制备α-细辛醚储库型贴片,考察其体外释药特性和离体皮肤经皮渗透性,筛选有效的透皮吸收促进剂,提高α-细辛醚的透皮吸收速率。方法:以1%的HPMC的醇性溶液为储库介质,以EVA膜为控释膜,制备α-细辛醚的储库型透皮贴片。用改良Franz扩散池进行人离体皮肤渗透实验,筛选透皮吸收促进剂,用HPLC测定α-细辛醚的含量并计算其透皮速率。结果:α-细辛醚的释放速率接近零级。30%乙醇和1%肉豆蔻酸异丙酯协同对α-细辛醚贴片的促渗效果最佳,透皮速率达到(20.67±1.33)μg.cm-2.h-1。结论:含乙醇和肉豆蔻酸异丙酯的α-细辛醚储库型贴片有较好的经皮渗透速率,可满足临床治疗要求。
Objective: To prepare the α-asarone reservoir patch and investigate its release and transdermal absorption characteristics in vitro.The efficient enhancers were chosen to improve the drug's permeation rate.Method: The α-asarone reservoir patch was prepared using 1%hydroxypropyl methylcellulose(HPMC) of ethanol solution as medium and ethylene vinyl acetate(EVA) membrane to control the release of drug.The Franz diffusion cel1s were used and several permeation enhancers were evaluated.High performance liquid chromatorgraphy(HPLC) was used to determine α-asarone's content and permeation rate.Result: The release mechanisms of α K-asarone patch in vitro coincided with zero-order kinetic.30% ethanol cooperates with 1% Isopropyl Myristate(IPM) have the best effect on permeation of the patch.The permeation rate reaches(20.67±1.33) μg·cm-2·h-1.Conclusion: Ethanol combined with IPM is good permeation enhancer,which facilitated the permeation of α K-asarone to fit the clinical requirements.However,the further studies of the skin's stimulation and bioavailability are needed.

关键词(KeyWords): α-细辛醚;经皮渗透;促渗剂;储库型;贴片;HPLC
α-asarone;transdermal;permeation enhancers;reservoir;patch;HPLC

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作者(Authors): 吴争;高建青;陈海靓;胡英;梁文权;
WU Zheng1,GAO Jian-qing1,CHEN Hai-liang1,HU Ying1,2,LIANG Wen-quan(1.Institute of pharmaceutics,Zhe jiang University,Hangzhou 310058,China;2.Zhejiang Pharmaceutical College,Ningbo 315100,China)

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