红花石蒜生物碱化学成分的研究Amaryllidaceae alkaloids from Lycoris radiata
胡疆;刘雁;李强;张丽芳;景年华;史俊友;吕涛;殷斯;彭天凤;郝珊瑚;
HU Jiang;LIU Yan;LI Qiang;ZHANG Li-fang;JING Nian-hua;SHI Jun-you;LYU Tao;YIN Si;PENG Tian-feng;HAO Shan-hu;Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University;Department of Public Courses,Qujing Medical College;Nuclear Medicine Department,General Hospital of Shenyang Military Region;
摘要(Abstract):
对红花石蒜Lycoris radiata鳞茎的生物碱类成分进行研究。采用硅胶、反向硅胶、凝胶及MCI-gel树脂等多种色谱技术,对红花石蒜的生物碱进行分离和纯化,并通过1H-NMR,13C-NMR和MS等波谱方法鉴定化合物的结构。从该植物鳞茎70%乙醇提取液的氯仿萃取部分中分离得到9个amaryllidaceae类生物碱,分别鉴定为(+)-N-methoxylcarbonyl-1,2-methylenedioxyl-isocorydione(1),isocorydione(2),8-demethyl-dehydrocrebanine(3),(+)-3-hydroxy-anhydrolycorine N-oxide(4),vasconine(5),pancratinine D(6),yemenine A(7),11-O-acetylhaemanthamine(8)和5,6-dihydro-5-methyl-2-hydroxyphenanthridine(9)。其中,化合物1为新化合物,化合物2~9为首次从该植物中分离得到。
Three aporphine-type alkaloids( 1-3),three lycorine-type alkaloids( 4-6),two crinane type alkaloids( 7,8) and one phenanthridine-type alkaloid( 9) were isolated from the chloroform soluble fraction of 70% ethanol extract of the bulbs of Lycoris radiata through various column chromatographies over silica gel,ODS,Sephadex LH-20 and MCI. Their structures were elucidated as( +)-N-methoxylcarbonyl-1,2-methylenedioxyl-isocorydione( 1),isocorydione( 2),8-demethyl-dehydrocrebanine( 3),( +)-3-hydroxy-anhydrolycorine N-oxide( 4),vasconine( 5),pancratinine D( 6),yemenine A( 7),11-O-acetylhaemanthamine( 8),and 5,6-dihydro-5-methyl-2-hydroxyphenanthridine( 9) based on their chemical and physicochemical properlies and spectroscopic data. Compound 1 was a new compound and alkaloids 2-9 were isolated and identified from this plant for the first time.
关键词(KeyWords):
红花石蒜;石蒜科;化学成分;生物碱类
Lycoris radiata;Amaryllidaceae;chemical constitutent;alkaloid
基金项目(Foundation): 国家自然科学基金项目(31760341);; 云南省应用基础研究计划项目(2016FD080);; 云南省高校科技创新团队项目(云教科(2014)14号)
作者(Author):
胡疆;刘雁;李强;张丽芳;景年华;史俊友;吕涛;殷斯;彭天凤;郝珊瑚;
HU Jiang;LIU Yan;LI Qiang;ZHANG Li-fang;JING Nian-hua;SHI Jun-you;LYU Tao;YIN Si;PENG Tian-feng;HAO Shan-hu;Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University;Department of Public Courses,Qujing Medical College;Nuclear Medicine Department,General Hospital of Shenyang Military Region;
Email:
DOI: 10.19540/j.cnki.cjcmm.20180115.016
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- 胡疆
- 刘雁
- 李强
- 张丽芳
- 景年华
- 史俊友
- 吕涛
- 殷斯
- 彭天凤
- 郝珊瑚
HU Jiang- LIU Yan
- LI Qiang
- ZHANG Li-fang
- JING Nian-hua
- SHI Jun-you
- LYU Tao
- YIN Si
- PENG Tian-feng
- HAO Shan-hu
- Institute of Characteristic Medicinal Resource of Ethnic Minorities
- Qujing Normal University
- Department of Public Courses
- Qujing Medical College
- Nuclear Medicine Department
- General Hospital of Shenyang Military Region
- 胡疆
- 刘雁
- 李强
- 张丽芳
- 景年华
- 史俊友
- 吕涛
- 殷斯
- 彭天凤
- 郝珊瑚
HU Jiang- LIU Yan
- LI Qiang
- ZHANG Li-fang
- JING Nian-hua
- SHI Jun-you
- LYU Tao
- YIN Si
- PENG Tian-feng
- HAO Shan-hu
- Institute of Characteristic Medicinal Resource of Ethnic Minorities
- Qujing Normal University
- Department of Public Courses
- Qujing Medical College
- Nuclear Medicine Department
- General Hospital of Shenyang Military Region