胡疆;刘雁;李强;张丽芳;景年华;史俊友;吕涛;殷斯;彭天凤;郝珊瑚;
HU Jiang;LIU Yan;LI Qiang;ZHANG Li-fang;JING Nian-hua;SHI Jun-you;LYU Tao;YIN Si;PENG Tian-feng;HAO Shan-hu;Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University;Department of Public Courses,Qujing Medical College;Nuclear Medicine Department,General Hospital of Shenyang Military Region;

• 1:曲靖师范学院少数民族特色药用资源研究所
• 2:曲靖医学高等专科学校公共课部
• 3:沈阳军区总医院核医科学

摘要(Abstract)：

对红花石蒜Lycoris radiata鳞茎的生物碱类成分进行研究。采用硅胶、反向硅胶、凝胶及MCI-gel树脂等多种色谱技术,对红花石蒜的生物碱进行分离和纯化,并通过1H-NMR,13C-NMR和MS等波谱方法鉴定化合物的结构。从该植物鳞茎70%乙醇提取液的氯仿萃取部分中分离得到9个amaryllidaceae类生物碱,分别鉴定为(+)-N-methoxylcarbonyl-1,2-methylenedioxyl-isocorydione(1),isocorydione(2),8-demethyl-dehydrocrebanine(3),(+)-3-hydroxy-anhydrolycorine N-oxide(4),vasconine(5),pancratinine D(6),yemenine A(7),11-O-acetylhaemanthamine(8)和5,6-dihydro-5-methyl-2-hydroxyphenanthridine(9)。其中,化合物1为新化合物,化合物2~9为首次从该植物中分离得到。
Three aporphine-type alkaloids( 1-3),three lycorine-type alkaloids( 4-6),two crinane type alkaloids( 7,8) and one phenanthridine-type alkaloid( 9) were isolated from the chloroform soluble fraction of 70% ethanol extract of the bulbs of Lycoris radiata through various column chromatographies over silica gel,ODS,Sephadex LH-20 and MCI. Their structures were elucidated as( +)-N-methoxylcarbonyl-1,2-methylenedioxyl-isocorydione( 1),isocorydione( 2),8-demethyl-dehydrocrebanine( 3),( +)-3-hydroxy-anhydrolycorine N-oxide( 4),vasconine( 5),pancratinine D( 6),yemenine A( 7),11-O-acetylhaemanthamine( 8),and 5,6-dihydro-5-methyl-2-hydroxyphenanthridine( 9) based on their chemical and physicochemical properlies and spectroscopic data. Compound 1 was a new compound and alkaloids 2-9 were isolated and identified from this plant for the first time.

关键词(KeyWords)： 红花石蒜;石蒜科;化学成分;生物碱类
Lycoris radiata;Amaryllidaceae;chemical constitutent;alkaloid

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(31760341);; 云南省应用基础研究计划项目(2016FD080);; 云南省高校科技创新团队项目(云教科(2014)14号)

作者(Author): 胡疆;刘雁;李强;张丽芳;景年华;史俊友;吕涛;殷斯;彭天凤;郝珊瑚;
HU Jiang;LIU Yan;LI Qiang;ZHANG Li-fang;JING Nian-hua;SHI Jun-you;LYU Tao;YIN Si;PENG Tian-feng;HAO Shan-hu;Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University;Department of Public Courses,Qujing Medical College;Nuclear Medicine Department,General Hospital of Shenyang Military Region;

Email:

DOI: 10.19540/j.cnki.cjcmm.20180115.016

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