韦琨,窦德强,裴玉萍,陈英杰

• 1:沈阳药科大学植化教研室
• 2:沈阳药科大学植化教研室
• 3:沈阳药科大学植化教研室
• 4:沈阳药科大学植化教研室 辽宁沈阳110016

摘要(Abstract)：

在与卡瓦胡椒做对比的基础上 ,就胡椒的生物碱、挥发油、有机酸、木脂素等多种化学成分及药理作用的研究进行了综述 ,并简介了其构效关系

关键词(KeyWords)： 胡椒;卡瓦胡椒;化学成分;药理作用;构效关系

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 韦琨,窦德强,裴玉萍,陈英杰

参考文献(References)：

• [1]　中国科学院中国植物志编辑委员会.中国植物志.第二十卷.第一分册.北京:科学出版社,1982.24.
• [2]　余传隆,黄泰康,丁志遵,等.中药辞海.北京:中国医药科技出版社,1993.16079
• [3]　郑虎占,董泽宏,佘　靖,等.中药现代研究与应用.第四卷.北京:学苑出版社,1998.3243.
• [4]　郭朝广.胡椒根治疗坐骨神经痛临床疗效观察.中药材,1992,15(10):44.
• [5]　AANewman.NaturalandSyntheticPepper flavoredSubstances.II.ChemProducts,1953,16:379.
• [6]　NobujiNakatani,MasakazuMiyakado,IsamuNakayama,etal.N Isobutyl11(3,4 methylenedioxy phenyl)2E ,4E ,10E unde catrienoicAmidefromPipernigrum.JpnKokaiTokkyoKoho,1979,117,476.
• [7]　ReikoInatani,NobujiNakatani,HidetsuguFuwa.StructureandSynthesisofNewPhenolicAmidesfromPipernigrumL ..AgricBoilChem,1981,45(3):667.
• [8]　NobyjiNakatari,ReikoInatani,HidetsuguFuwa.ConstituentsofPepper.PartI .StructureandSynthesisofTwoPhenolicAmidesfromPipernigrumL ..AgricBoilChem,1980,44(12):2831.
• [9]　HelenCFSu,RobertHorvat.Isolatian,IdentificationandInsec ticidalPropertiesofPipernigrumAmides.JAgricFoodChem,1981,29(1):115.
• [10]　NobyjiNakatari.ReikoInatani.ConstituentsofPepper.PartⅢ.IsobutylAmidesfromPepper(PipernigrumL .).AgricBi olChem,1981,45(6):1473.
• [11]　MasakazuMiyakado,IsamuNakayama,NbuoOhno,etal.Structure,ChemistryandActionsofthePiperaceaeamidesNewInsecticidalConstituentsIsolatedfromthePepperPlant.CurrThemesTropSci,1983,(2):369.
• [12]　HajimeOhigashi,SatoshiNishimuro,KoichiKoshimizu.Larva developmentInhibitorsofBlackPepper.BullInstChemResKy otoUniv,1983,61(2):104.
• [13]　FumiyukiKiuchi,NorioNakamura,YoshisukeTsuda,etal.StudiesonCrudeDrugsEffectiveonVisuralLarvaMigrans.Ⅳ.IsolationandIdentificationofLarvicidalPrinciplesInPepper.ChemPharmBull,1988,36(7):2452.
• [14]　BSSiddiqui,SBegum,TGulzar,etal.AnAmidefromFruitsofPipernigrum.Phytochemistry,1997,45(8):1617.
• [15]　RdolfGrene,WolfgangFreist,HelgeNeumann,etal.ChemicalConstituentsofBlackPepper.ChemBer,1970,103(12):3752.
• [16]　JamesJTraxler.Piperamine,APungentComponentofBlackPepper.JAgrFoodChem,1971,19(6):1135.
• [17]　PVSrinivas,MadhusudanaRao.IsopiperoleinB :AnAlkamidefromPipernigrum.Phytochemistry,1999,52(5):957.
• [18]　PSVariyar,CBandyopadhyay.EstimationofPhenolicCom poundsinGreenPepperBerries(PipernigrumL .)byHightPerformanceLiquidChromatography.Chromatographia,1994,39(11/12):743.
• [19]　YFujiwara,KNaithou,TMiyazaki,etal.TwoNewAlkaloids,PipercyclobutanamidesAandBfromPipernigrum.Tetrahe dronLetters,2001,42(13):2497.
• [20]　HansAchenbach,WolfgangKarl.IsolationofTwoNewPyrroli didesfromPipermethysticum.ChemBer,1970,103(8):2536.
• [21]　RogerMSmith.Pipermethystine,ANovelPyridoneAlkaloidfromPipermethysticum.Tetrahedron,1979,35(3):437.
• [22]　CBandyopadhyay,PrasadSVariyar.OntheVolatilesofPepperPlant(PipernigrumL .).PafaiJ ,1988,10(1):25.
• [23]　敖　平,胡世林.胡椒根挥发油的化学成分及其微量元素测定.中国中药杂志,1998,23(1):42.
• [24]　MGopalakrishnan,NirmalaMenon,KPPadmakumari,etal.GCAnalysisandOdorProfilesofFourNewIndianGenotypesofPipernigrumL ..JEssentOilRes,1993,5(3):247.
• [25]　IHQureshi,JHZaidi,MArif,etal.TraceElementAnalysisofFoodSpicesbyInstrumentalNeutronActivationAnalysis.I .TraceElementsinFoodSpicesBelongingtoUmbelliferae,Myr taceae,Piper aceae,ZingiberaceaeandLauraceaeFamilies.IntJEnvironAnalChem,1991,43(1):25.
• [26]　CDDaulatabad,GMMulla,AMMirajkar.VerrolicandCyclo propenoicFattyAcidsinPipernigrumSeedOil.FettWissTechnol,1995,97(12):453.
• [27]　HansAchenbach,WolfgangKarl.ConstituentsofPipermethys ticum.Ⅲ.InvestigationoftheAcidsfromKava(Pipermethys ticum).ChemBer,1971,104(5):1468.
• [28]　MASumathykutty.LignansfromLeavesofPipernigrumL ..IndianJChem,1988,27B :388.
• [29]　HiroyukiInagawa,TakashiNishizawa,DaisukeTsukioka,etal.HomeostasisAsRegulatedbyActivatedMacrophage.Ⅱ.LPSofPlantOriginotherthanWheatFlourandTheirConcomitantBac teria.ChemPharmBull,1992,40(4):994.
• [30]　HSauer,RHaensel.ComponentsofPiperSpecies.ⅩⅥ.KavaLactonesandFlavonoidsfromAnEndemicPiperspeciesofNewGuinea.PlantaMed,1967,15(4),443.
• [31]　HansAchenbach,GAchenbach.Dihydrokawain5 ol,ANewAlcoholfromPipermethysticum.TetrachedronLett,1970,(37):3259.
• [32]　HansAchenbach,WolegangKarl,WalterRegel.ConstituentsofPipermethysticum.Ⅴ.11Hydroxy12 methoxydihydrokawainand11,12Dimethoxydihydrokawain,TwoNewKavaLactonesfomPipermethysticum.ChemBer,1972,105(7):2182.
• [33]　RHaensel,PBachr,JElich.IsolationandCharacterizationofTwoNewPigmentsfromPipermethysticumRhizones.ArchPharm,1961,294:739.
• [34]　CPDutta,LalaPKRay,AMrsChatterjea,etal.ConstituentsofPipermethysticum.Phytochemis try,1972,11(9):2891.
• [35]　CPDutta,LalaPKRay,AMrsChatterjea,etal.ConstituentsofElavokawainC .IndianJChem,1973,11(5):509.
• [36]　PerJossang,DariusMalho.ChromatographyorNonboundThickLayersofConstituentsofPipermethysticumRhizone:IsolationofTwoNewKetones,Cinnamylideneacetoneand3,4(methylenedioxy)cinnamylideneacetone.JChromatogr,1967,31(2):375.
• [37]　裴印权,岳　微,崔景荣,等.胡椒碱衍生物的中枢药理作用研究.药学学报,1980,15(4):198.
• [38]　北京医学院基础部药理教研组.胡椒碱的抗惊和镇静作用.北京医学院学报,1974,(4):217.
• [39]　JosephPBuckley,AngeloRFurgiuele,MaureneJO’Hara.PharmacologyofKavaUS ,PublicHealthServPubl,1645:145.
• [40]　RKretzschmar,HansJoachimMeyer.InfluenceofNatural5,6 hydratedKava rootPyronesonIsolatedHeartPreparationsandTheirAntifibrillatoryActivityintheAnimal.ArchIntPharmaco dynTher,1968,175(1):1.
• [41]　RKretzschmar,HansJoachimMeyer,HJTeschendorf,etal.AntagonisticActionof5,6 hydrogenatedα pyronesoftheKavaRoot(Pipermethysticum)AgainstStrychninePoisoningandEx perimentalLocaltetanus.ArchIntPharmacodynTher,1969,182(2):251.
• [42]　RKretzschmar,HansJoachimMeyer.ComparativeStudiesontheAnticonvulsiveActivityofPyroneCompoundsfromPipermethysticum.ArchIntPharmacodynTher,1969,177(2):261.
• [43]　DDJamieson,PHDuffield.TheAntinociceptiveActionsofKa vaCompoundsinMice.ClinExpPharmacolPhysiol,1990,17(7):495.
• [44]　DDJamieson,PHDuffield,DCheng,etal.ComparisonoftheCentralNervousSystemActivityoftheAqueousandLipidEx tractofKava(Pipermethysticum).ArchIntPharmacodynTher,1989,301:66.
• [45]　DHDullield,AMDueeield.EffectofAqueousandLipid solubleExtractsofKavaontheConditionedAvoidanceResponseinTats.ArchIntPharmacodynTher,1989,301:81.
• [46]　UlbikeSeitz,AlmutSchuele,JohannesGlectz.
• [3H]MonoamineUptakeInhibitionPropertiesofKavaPyrones.PlantaMed,1997,63(6):548.
• [47]　SiedySallstromBaum,ReginaHill,HansRommelspacher.Ef fectofKavaExtractandIndividualKavapyronesonNeuroTrans mitterLevelsintheNuleusAccumbersofRats.ProgNeuroPsy chophar macolBiolPsychiatry,1998,22(7):1105.
• [48]　RUebelhack,LFranke,HJSchewe.InhibitionofPlateletMAO BbyKavaPyroneEnrichedExtractfromPipermethys ticumfroster(kawa kava).Pharmacopsychiatry,1998,31(5):187.
• [49]　敖　平,李　斌,廖福龙,等.胡椒根乙醇提取物药理活性研究.中医药学报,1998,(3):61.
• [50]　InduBalaKoul,AruanaKapil.EvaluationoftheLiverProtectivePotentialofPiperine,AnActivePrincipleofBlackandLongPep pers.PlantaMed,1993,59(5):413.
• [51]　ASingh,ARRao.EvaluationoftheModulatoryInfluenceofBlackPepper(PipernigrumL .)ontheHepaticDetoxicationSystem.CancerLett(Shannon,Irel.),1993,72(12):5.
• [52]　NNalini,KSabitha,PViswanathan,etal.SpicesandGlyco proteinMetabolisminExperimentalColonCancerRats.MedSciRes,1998,26(11):781.
• [53]　MASumathykutty.LignansFromLeavesofPipernigrumL ..IndianJChem,1988,27B :388.
• [54]　KJPradhan,PSVariyar,JRBandekar.AntimicrobialActivityofNovelPhenolicCompoundsfromGreenPepper(PipernigrumL .).LebensmWissTechnol,1999,32(2):121.
• [55]　RHaensel,DWeiss,BSchmidt.FungistaticEffectoftheKavaDrugandItsComponents.PlantaMed,1966,14(1):1.
• [56]　UdayKSom,CPDutta,GMSarkar,etal.AntibacterialStud ieswiththeCompoundsIsolatedfromPipermethysticumForst.NatlAcadSciLett,1985,8(4):109.
• [57]　RogerMSmith,SDutta,CPDutt.StudiesonGenusPiperⅩ:AmebicidalActivityofCompoundsIsolatedfromPipermethys ticumForst..NatlAcadSciLett,1983,6(8):271.
• [58]　FirozaKhanom,HiroshiKayahara,KojiTadasa.TyrosinaseIn hibitoryActivityofBangladeshiIndigenousMedicinalPlants.BiosciBiotechnolBiochem,2000,64(9):1967.
• [59]　HJDamienDorman,PeterSurai,StanleyGDeans.InVitroAntioxidantActivityofANumberofPlantEssentialOilsandPhytoconstituents.JournalofEssentialOilResearch,2000,12(2):241.
• [60]　AMMujumdar,JNDhuley,VKDeshmukh,etal.EffectofPiperineonBioavailabilityofOxyphenylbutazoneinRats.IndianDrugs,1999,36(2),123.
• [61]　AnnuKhajuria,Usha.Zutshi,KLBedi.IntestinalPermeabilityCharacteristicsofPiperine:AnActiveAlkaloidfromPeppersandA .BioavailabilityEnhancer.IndianJExpBiol,1998,36(1):46.
• [62]　CordBackhauss,JosefKrieglstein.ExtractofKava(Pipermethysticum)andItsMethysticumConstituentsProtectBrainTissueAgainstIschemicDamageinRodents.EurJPharmacol,1992,215(23):265.
• [63]　JohannesGleitz,ArneBeile,PetraWilken,etal.Antithrombot icActionoftheKavaPyrone(+) kavainPreparedfromPipermethysticumonHumanPlatelets.PlantaMed,1997,63(1):27.
• [64]　RKretzschmar,HansJoachimMeyer,HJTeschendorf,etal.SpasmolyticActivityofArylSubstitutαPyronesandAqueoudEx tractsofPipermethysticum.ArchIntPharmacodynTher,1969,180(2):475.