中国中药杂志

2014, v.39(06) 1011-1015

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狗脊不同炮制品水煎液抗维甲酸致雄性大鼠骨质疏松症研究
Study on decoction's effect of different processed rhizomes of Cibotium barometz on retinoic acid induced male rats osteoporosis

徐钢;孙娜;赵敏杰;鞠成国;贾天柱;
XU Gang;SUN Na;ZHAO Min-jie;JU Cheng-guo;JIA Tian-zhu;School of Pharmacy Liaoning University of Traditional Chinese Medicine;Chinese Materia Medica Processing Engineering Center of Liaoning Province;The Key Laboratory of State Administration of Traditional Chinese Medicine;

摘要(Abstract):

该研究比较了生狗脊、酒狗脊、盐狗脊、烫狗脊和蒸狗脊的水煎液HPLC图谱,在此基础上,以砂烫骨碎补水煎液为阳性组,又比较了各组灌胃水煎液(质量浓度为104.2 g·L-1)4周后对维甲酸致骨质疏松雄性大鼠血清抗酒石酸酸性磷酸酶s-TRAP水平和作用机制指标血清护骨素OPG,血Ca和P,IL-6,TNF-α和IL-1水平及总评分的影响。结果表明,酒狗脊和砂烫狗脊效果较好,而蒸狗脊、盐狗脊以及生狗脊作用次之。在炮制方法的选择方面,加热方式中干热的砂烫法优于湿热的水蒸法,辅料中黄酒优于食盐。该结果为阐明狗脊炮制原理和抗骨质疏松症作用机制提供参考。
This study compared the decoction's HPLC figures of the different processed rhizomes of Cibotium barometz including the raw,the sand-baked,the wined,the steamed and the salted,on the basis of which,with the sand-baked Drynaria fortunei decoction as the positive control group,comparingall groups' decoction,concentration of which was 104. 2 g·L- 1,for 4 weeks,by their effects( s-TRAP and total scores of OPG,Ca,P,IL-6,TNF-α and IL-1) on retinoic acid induced male rats osteoporosis. The experiment results showed the sand-baked and the wined were better than the steamed,the salted and the raw; in the processing methods' selection,the sand-baked was a better heating method than the steamed and the rice wine was the better excipient than the salt. It provided a reference to explain the processing principle of rhizomes of C. barometz and work mechanism of anti-osteoporosis.

关键词(KeyWords): 狗脊;炮制品;水煎液;维甲酸;骨质疏松症;破骨细胞
Cibotium barometz;processed products;decoction;retinoic acid;osteoporosis;osteoclast

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(30973938)

作者(Authors): 徐钢;孙娜;赵敏杰;鞠成国;贾天柱;
XU Gang;SUN Na;ZHAO Min-jie;JU Cheng-guo;JIA Tian-zhu;School of Pharmacy Liaoning University of Traditional Chinese Medicine;Chinese Materia Medica Processing Engineering Center of Liaoning Province;The Key Laboratory of State Administration of Traditional Chinese Medicine;

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