中国中药杂志

2006, (23) 1947-1950

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正交设计喷雾干燥工艺制备麦冬皂苷肠溶微球
Studies on using spray drying technique in preparing Ophiopogon Japonicus saponin enteric microsphere by orthogonal experimental design

沈岚;冯怡;徐德生;林晓;
SHEN Lan,FENG Yi,XU De-sheng,LIN Xiao (Shanghai University of traditional Chinese medicine,Shanghai 201203,China;Shuguang Hospital,Shanghai 200021,China)

摘要(Abstract):

目的:探索喷雾干燥工艺制备麦冬皂苷肠溶微球的最优工艺参数。方法:以外观形态、包封率、收率等为指标,采用正交设计对喷雾干燥工艺参数进行优选。结果:最优工艺参数:进风温度90℃,加料速度10 mL.m in-1,雾化器转速50 r.m in-1。结论:麦冬皂苷肠溶微球质量符合预期要求;影响微球成型的主要因素为进风温度;喷雾干燥技术制备中药微球有利于工业化生产。
Objective: To explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique.Method: The best technique parameters were investigated by orthogonal experimental design and by the target,such as surface appearances,encapsulated efficiency,etc.Result: The best technique parameters included the inlet temperature(90 ℃),the feeding speed(10 mL·min(-1)),and the rotate speed of atomizer(50 r·min(-1)),and the rotate speed of atomizer(50 r·min(-1)).Conclusion: Ophiopogon japonicus saponin enteric microsphere accorded with the expecting demand.The main influencing factor was inlet temperature.It is suitable to industrialize in preparing Traditional Chinese Medicine microsphere.

关键词(KeyWords): 喷雾干燥;正交设计;麦冬皂苷肠溶微球
spray drying technique;orthogonal experimental design;Ophiopogon Japonicus saponin enteric microsphere

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作者(Authors): 沈岚;冯怡;徐德生;林晓;
SHEN Lan,FENG Yi,XU De-sheng,LIN Xiao (Shanghai University of traditional Chinese medicine,Shanghai 201203,China;Shuguang Hospital,Shanghai 200021,China)

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