中国中药杂志

2020, v.45(16) 3759-3769

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五味子在肝脏疾病防治中的应用及其作用机制研究进展
Research progress in application and mechanism of Schisandrae Chinensis Fructus for prevention and treatment of liver diseases

张雯;朱雅迪;张起尧;马丽娟;杨凌;郭文治;葛广波;
ZHANG Wen;ZHU Ya-di;ZHANG Qi-yao;MA Li-juan;YANG Ling;GUO Wen-zhi;GE Guang-bo;Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Organ Transplantation Technology and Application Engineering;Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine;

摘要(Abstract):

五味子为木兰科植物五味子Schisandra chinensis(习称"北五味子")或华中五味子S.shenanthera(习称"南五味子")的成熟果实。五味子中含有木脂素类、挥发油类、多糖类和有机酸类等多种化学成分,其中木脂素类化合物是其特征性活性成分。临床研究发现五味子及其制品对病毒性肝炎、药物性肝损伤、肝硬化、肝衰竭等多种肝脏疾病具有较好的防治作用。现代药理学研究表明五味子具有抗炎、抗氧化、抗癌、调控核受体、抗病毒、调节细胞色素P450酶、抑制肝细胞凋亡、促进肝再生等多种药理活性。该文对五味子在肝脏疾病防治中的应用及其作用机制进行了系统综述,以期为五味子相关保肝药物的开发及五味子制品的临床合理应用提供指导。
Schisandra is the mature fruit of Schisandra chinensis(known as "north Schisandra") or S. shenanthera(known as "south Schisandra"). S. chinensis contains a variety of lignans, volatile oils, polysaccharides, organic acids and other chemical constituents; among them, lignans are recognized as the characteristic active components. Clinical studies have found that Schisandra and Schisandra-related products have a better effect in the prevention and treatment of viral hepatitis, drug-induced liver injury, liver cirrhosis, liver failure and other liver diseases. Modern pharmacological studies have demonstrated that Schisandra has a variety of pharmacological activities, such as anti-inflammation, antioxidation, anticancer, regulation of nuclear receptor, antivirus, regulation of cytochrome P450 enzyme, inhibition of liver cell apoptosis and promotion of liver regeneration. This paper reviews the studies about the applications and mechanism of Schisandra in the prevention and treatment of liver diseases, in the expectation of providing guidance for the development of hepatoprotective drugs from Schisandra and the clinical applications of Schisandra-related products.

关键词(KeyWords): 五味子;木脂素类;保肝作用;临床应用;作用机制
Schisandra chinensis;lignans;hepatoprotective effect;clinical application;mechanisms

Abstract:

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基金项目(Foundation): 国家重点研发计划项目(2017YFC1700200,2017YFC1702000,2020YFC0845400);; 国家自然科学基金项目(81671958,U1604282,81922070,81973286);; 上海市优秀学术带头人计划项目(18XD1403600);; 上海市曙光学者计划项目(18SG40);; 河南省卫计委省部共建项目(SBGJ2018002);; 河南省高校创新人才项目(19HASTIT003)

作者(Author): 张雯;朱雅迪;张起尧;马丽娟;杨凌;郭文治;葛广波;
ZHANG Wen;ZHU Ya-di;ZHANG Qi-yao;MA Li-juan;YANG Ling;GUO Wen-zhi;GE Guang-bo;Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Organ Transplantation Technology and Application Engineering;Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine;

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