中国中药杂志

2010, v.35(19) 2637-2640

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中药质量生物测定的思考与实践——以板蓝根为例
Application of bioassay in quality control of Chinese materia medica-taking Radix Isatidis as an example

鄢丹;任永申;骆骄阳;李寒冰;冯雪;肖小河;
YAN Dan1, REN Yongshen1, LUO Jiaoyang1, LI Hanbing2, FENG Xue1, XIAO Xiaohe1(1. Institute of Chinese Meteria Medica, 302 Hospital of PLA, Beijing 100039, China; 2. Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China)

摘要(Abstract):

生物测定是构建符合中医药特点的中药质量控制模式和方法的核心内容。从生物测定基本内涵出发,结合课题组在该领域的研究体会,以板蓝根质量生物测定为实例,就生物测定在中药质量控制中的作用与地位、应用范围以及如何解决生物测定建立过程中的两大关键问题(参照物和测定方法)等进行阐述,以期从实际操作层面为中药质量生物测定的发展与完善提供参考。
Bioassay,which construct the characteristics consistents with Chinese medical science, is the core mode and methods for the quality control of Chinese materia medica. Taking the bioassay of Radix Isatidis as an example, the contribution, status and application of bioassay in the quality control of Chinese materia medica were introduced in this article, and two key issue (the selection of reference and measurement methods) in the process of establishing bioassay were also explained. This article expects to provide a reference for the development and improvement of the bioassay of Chinese materia medica in a practical manipulation level.

关键词(KeyWords): 中药;质量控制;生物测定;板蓝根
Chinese materia medica; quality control; bioassay; Radix Isatidis

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基金项目(Foundation): 国家自然科学基金项目(30873385);; 国家“重大新药创制”科技重大专项(2009ZX09502-022,2009ZX09308-005)

作者(Author): 鄢丹;任永申;骆骄阳;李寒冰;冯雪;肖小河;
YAN Dan1, REN Yongshen1, LUO Jiaoyang1, LI Hanbing2, FENG Xue1, XIAO Xiaohe1(1. Institute of Chinese Meteria Medica, 302 Hospital of PLA, Beijing 100039, China; 2. Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China)

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