中国中药杂志

2015, v.40(09) 1666-1669

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睡眠剥夺对冠心病的影响及中医药防治进展
Impact of sleep deprivation on coronary heart disease and progress in prevention and treatment with traditional Chinese medicines

袁蓉;王阶;郭丽丽;
YUAN Rong;WANG Jie;GUO Li-li;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicine;

摘要(Abstract):

睡眠剥夺已成为冠心病风险的独立预测因子,目前和逐渐升高的心血管发病率和死亡率密切相关。该文回顾了现代医学睡眠剥夺对冠心病的影响及中医药防治的理法方药研究,发现睡眠剥夺通过增加冠心病危险因素,引起自主神经功能、激素代谢功能、内皮功能紊乱及炎症反应,影响机体的各个方面而诱发或加重冠心病。在中医"心主血脉","心主神志"的理论基础上,笔者认为中医药"调心安神"通过"双心"同调,多靶点多途径作用于心血管危险因素的各个环节,可改善睡眠并减少睡眠剥夺引起的冠心病危险因素,为冠心病的防治提供了新思路。
Sleep deprivation( SD) has been taken as an independent predictor for cardiovascular risks,which was closely related to the increased morbidity and mortality in coronary heart disease( CHD). In this article,after reviewing the impact of modern medical method sleep deprivation on CHD and studies on principle method recipe medicines for preventing and treating CHD,the authors observed the autonomic nerve dysfunction,hormonal metabolism dysfunction,endothelial dysfunction and inflammatory responses after sleep deprivation,which can cause or aggravate CHD. On the basis of the traditional Chinese medicine theories of " heart dominating the blood and vessels and the mind",the authors considered that traditional Chinese medicines can tonify heart and soothe the nerves,reducing all of the risk factors through multi-target and multi-pathway,and improve sleep and decrease the risk factors caused by sleep deprivation,which provides a new idea for the prevention and treatment of CHD.

关键词(KeyWords): 心肌缺血;心血管病;失眠;危险因素;中医
myocardial ischemia;cardiovascular disease;insomnia;risk factors;Chinese medicine

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2012ZX09102-201-006)

作者(Authors): 袁蓉;王阶;郭丽丽;
YUAN Rong;WANG Jie;GUO Li-li;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicine;

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