中国中药杂志

2015, v.40(06) 999-1004

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桂枝茯苓方治疗痛经、盆腔炎以及子宫肌瘤的活性成分和分子作用机制研究
Study of effective components and molecular mechanism for Guizhi Fuling formula treatment of dysmenorrhea,pelvic inflammatory disease and uterine fibroids

柯志鹏;张新庄;丁玥;曹泽彧;李娜;曹亮;王团结;章晨峰;丁岗;王振中;萧伟;徐筱杰;
KE Zhi-peng;ZHANG Xin-zhuang;DING Yue;CAO Ze-yu;LI Na;CAO Liang;WANG Tuan-jie;ZHANG Chen-feng;DING Gang;WANG Zhen-zhong;XIAO Wei;XU Xiao-jie;Jiangsu Kanion Pharmarceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;College of Chemistry and Molecular Engineering,Peking University;

摘要(Abstract):

该研究采用网络药理学的方法,探讨桂枝茯苓方治疗痛经、盆腔炎以及子宫肌瘤的主要活性成分和潜在的分子作用机制。药物-靶点网络特征分析显示分子网络度较高的多为甾醇类和五环三萜类化合物,它们在抗炎、解热镇痛、抗肿瘤以及免疫调节等方面具有较好的治疗作用;另一方面网络度较高的靶点多与炎症反应、凝血系统、血管形成、平滑肌收缩以及细胞增殖等环节有关。进一步的靶点-通路网络分析结果显示这些靶点与调控子宫平滑肌增殖、抑制子宫内新生血管形成、改善血液循环、降低性激素分泌、缓解子宫平滑肌收缩、抑制花生四烯酸代谢以及其他炎症反应等6个环节密切相关,从而揭示出其治疗痛经、盆腔炎以及子宫肌瘤的主要分子机制。该研究表明桂枝茯苓方可通过多个活性成分作用于多个靶点,调控21条生物通路,来治疗盆腔炎、痛经及子宫肌瘤。
In this study,the active components and potential molecular mechanism of Guizhi Fuling formula in treatment on dysmenorrhea,pelvic inflammation,and hysteromyoma were investigated using network pharmacological methods. Sterols and pentacyclic triterpenes,with high moleculal network degree,revealed promising effects on anti-inflammatory,analgesic,anti-tumor,and immuneregulation,according to D-T network analysis. On the other hand,the targets with high degree were involved in inflammatory,coagulation,angiopoiesis,smooth muscle contraction,and cell reproduction,which showed the novel function in anti-dysmenorrhea,pelvic inflammation,and hysteromyoma. Furthermore,the formula was indicated to play a key role in smooth muscle proliferation,inhibition of new vessels,circulation improvement,reduction of hormone secretion,alleviation of smooth muscle,block of arachidonic acid metabolism,and inflammation in uterus. Thus,the main mechanism of Guizhi Fuling formula was summarized. In conclusion,Guizhi Fuling formula was proven to alleviated dysmenorrhea,pelvic inflammation,and hysteromyoma by acting on multiple targets through several bioactive compounds,regulating 21 biological pathways.

关键词(KeyWords): 中药;网络药理学;分子对接;痛经;盆腔炎;子宫肌瘤
herb;network pharmacology;molecular docking;dysmenorrhea;pelvic inflammatory disease;uterine fibroids

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 柯志鹏;张新庄;丁玥;曹泽彧;李娜;曹亮;王团结;章晨峰;丁岗;王振中;萧伟;徐筱杰;
KE Zhi-peng;ZHANG Xin-zhuang;DING Yue;CAO Ze-yu;LI Na;CAO Liang;WANG Tuan-jie;ZHANG Chen-feng;DING Gang;WANG Zhen-zhong;XIAO Wei;XU Xiao-jie;Jiangsu Kanion Pharmarceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;College of Chemistry and Molecular Engineering,Peking University;

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