中国中药杂志

2018, v.43(20) 4062-4068

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石菖蒲挥发油自纳米乳的制备与质量评价
Preparation and quality evaluation of volatile oil from Acori Tatarinowii Rhizoma self-nanoemulsion

钟芮娜;汪小涵;王欣桐;申宝德;沈成英;王镜;韩丽;袁海龙;
ZHONG Rui-na;WANG Xiao-han;WANG Xin-tong;SHEN Bao-de;SHEN Cheng-ying;WANG Jing;HAN Li;YUAN Hai-long;College of Pharmacy,Chengdu University of Traditional Chinese Medicine;Department of Pharmacy,Air Force General Hospital,PLA;

摘要(Abstract):

为增加石菖蒲挥发油的溶解度,该研究拟将其制成自纳米乳制剂。通过相容性研究、辅料配伍试验、伪三元相图的绘制初步筛选处方,以粒径、载药量为指标,采用Box-Behnken效应面法优化处方,并对最优处方的自纳米乳制剂进行表征、体外溶出评价。结果显示,石菖蒲挥发油自纳米乳的最优处方为:41. 7%石菖蒲挥发油、46. 8%聚氧乙烯脱水山梨醇单油酸酯、11. 5%PEG-400;所制得的自纳米乳澄清透明,载药量为(192. 77±1. 64) mg·g-1,粒径为(53. 20±0. 94) nm,PDI为0. 230±0. 013,Zeta电位为(-12. 2±0. 7) m V;在体外溶出度实验中,石菖蒲挥发油自纳米乳明显高于石菖蒲挥发油。该研究中石菖蒲挥发油直接作为自纳米乳中的油相,处方更简单且载药量更高,制得的自纳米乳符合相关的质量要求,为挥发油的制剂研究提供了一定的参考。
In order to increase the solubility of volatile oil from Acori Tatarinowii Rhizoma,this study was to prepare self-nanoemulsion of volatile oil from Acori Tatarinowii Rhizoma. The prescriptions were preliminarily screened by miscibility studies,excipient compatibility tests,and pseudo-ternary phase diagrams,and then the optimal formulation was obtained by using the Box-Behnken response surface method,with particle size and drug-loading rate as the indicators. The self-nanoemulsion prepared by optimal prescription was characterized and evaluated for in vitro dissolution. The results showed that the optimal prescription for this volatile oil self-nanoemulsion was as follows: 41. 7% volatile oil,46. 8% Tween-80,and 11. 5% PEG-400. The prepared self-nanoemulsion was clear and transparent,with drug-loading of(192. 77 ± 1. 64) mg·g-1,particle diameter of(53. 20 ± 0. 94) nm,polydispersity index of0. 230 ± 0. 013,and Zeta potential of(-12. 2 ± 0. 7) m V. The in vitro dissolution of self-nanoemulsion was higher than that of volatile oil. In this research,volatile oil served as the oil phase in self-nanoemulsion,so the prescription was simpler and the drug loading rate was higher. The prepared self-nanoemulsion complied with the relevant quality requirements,providing a reference for the preparation of volatile oil formulations.

关键词(KeyWords): 石菖蒲挥发油;自纳米乳;伪三元相图;Box-Behnken效应面法;质量评价
volatile oil from Acori Tatarinowii Rhizoma;self-nanoemulsion;pseudo-ternary phase diagram;Box-Behnken response surface methodology;quality evaluation

Abstract:

Keywords:

基金项目(Foundation): 军队后勤科研重点项目(BKJ16J011);; 全军重大科研计划项目(BKJ16J025);; 全军医学科技青年培育计划拔尖项目(17QNP028)

作者(Author): 钟芮娜;汪小涵;王欣桐;申宝德;沈成英;王镜;韩丽;袁海龙;
ZHONG Rui-na;WANG Xiao-han;WANG Xin-tong;SHEN Bao-de;SHEN Cheng-ying;WANG Jing;HAN Li;YUAN Hai-long;College of Pharmacy,Chengdu University of Traditional Chinese Medicine;Department of Pharmacy,Air Force General Hospital,PLA;

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DOI: 10.19540/j.cnki.cjcmm.20180726.016

参考文献(References):

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