中国中药杂志

2016, v.41(04) 683-688

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Box-Behnken法中试规模下优化小青龙颗粒超声提取工艺
Optimization of ultrasonic extraction process for Xiaoqinglong granules by Box-Behnken in condition of medium scale

王正宽;石晓朦;刘圆;张庆芬;吴建雄;毕宇安;王振中;萧伟;
WANG Zheng-kuan;SHI Xiao-meng;LIU Yuan;ZHANG Qing-fen;WU Jian-xiong;BI Yu-an;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification;

摘要(Abstract):

在中试规模下考察超声技术在小青龙颗粒提取过程中的最佳条件。以单因素试验考察,确定各因素影响趋势及范围;以Box-Behnken法进行优化,检测药液中芍药苷、盐酸麻黄碱、甘草酸的含量,分别计算其提取率并进行综合评价,以其作为小青龙颗粒超声提取效果的评判依据。结果显示,小青龙颗粒超声提取的最佳工艺为超声功率600 W,液固比10∶1,提取31 min,在此条件下小青龙颗粒提取率预测值为85.90%,验证值为85.87%。该文所建立的数学模型(P<0.01)有意义,可对小青龙颗粒超声提取工艺进行分析和预测。
This paper is to investigate the optimization conditions of ultrasonic technique for extraction process of Xiaoqinglong granules in medium scale. First of all,single factor experiment was used to determine the overall impact tendency and range of each factor;secondly,Box-Behnken method was used for optimization and detecting the content of paeoniflorin,ephedrine hydrochloride,glycyrrhizic acid of the liquid medicine. Their respective extraction rate was calculated and the comprehensive evaluation was carried out. The results were used as the evaluation basis for the efficacy of Xiaoqinglong granules ultrasonic extraction. The test results showed that the optimum extraction process of Xiaoqinglong granules by ultrasonic extraction was under the following conditions: ultrasonic power 600 W,liquid-solid ratio 10∶ 1,extraction for 31 min. Under this condition,the predicted value of extraction rate for Xiaoqinglong granules was 85. 90%,and the test value was 85. 87%. The mathematical model( P < 0. 01) established in this paper was significant,and can be used for the analysis and prediction of the ultrasonic extraction process of Xiaoqinglong granules.

关键词(KeyWords): 小青龙颗粒;超声提取;单因素;Box-Behnken法;芍药苷;盐酸麻黄碱;甘草酸
Xiaoqinglong granule;ultrasonic extraction;single factor;Box-Behnken method;paeoniflorin;ephedrine hydrochloride;glycyrrhizic acid

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 王正宽;石晓朦;刘圆;张庆芬;吴建雄;毕宇安;王振中;萧伟;
WANG Zheng-kuan;SHI Xiao-meng;LIU Yuan;ZHANG Qing-fen;WU Jian-xiong;BI Yu-an;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification;

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