中国中药杂志

2017, v.42(22) 4277-4281

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中国黄花蒿中青蒿素含量空间分布特征分析
Analysis of spatial distribution of artemisinin in Artemisia annua in China

张小波;郭兰萍;邱智东;曲晓波;王慧;景志贤;黄璐琦;
ZHANG Xiao-bo;GUO Lan-ping;QIU Zhi-dong;QU Xiao-bo;WANG Hui;JING Zhi-xian;HUANG Lu-qi;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medical,China Academy of Chinese Medical Sciences;College of Pharmacy,Changchun University of Chinese Medicine;

摘要(Abstract):

道地药材指经过中医临床长期应用优选出来的,产在特定地域,受到特定生产加工方式影响,较其他地区所产同种药材品质佳、疗效好且质量稳定,具有较高的知名度的药材。道地药材是我国几千年悠久文明史、中医中药发展史形成的特有概念,根据道地药材的定义,可以看出不同地域之间的同种药材在质量和疗效等方面存在一定的差异性,在特定区域还存在一定的相似性。该文应用空间统计分析方法,对中国各地黄花蒿中青蒿素含量空间分布特征进行分析。(1)采用"I系数"对各地青蒿素含量的空间自相关性进行分析,结果显示,各省青蒿素含量存在着显著的、正的空间自相关;各省青蒿素含量高低并非随机分布,而是具有明显的空间聚集特征。(2)采用"G统计量"对各地青蒿素含量的空间差异性进行分析,结果显示,总体上青蒿素含量高的区域分布在西南地区,在空间上呈现连片分布,青蒿素含量趋于高值空间聚集;天津市和辽宁省青蒿素含量较低,青蒿素含量趋于低值空间聚集;其他省份青蒿素含量属于高值和低值过渡区域。(3)基于各省青蒿素含量一个指标,采用"Moran散点图"对各区域青蒿素含量空间关联关系进行分析,结果显示:广西、重庆等9个省市的青蒿素含量属于高值聚集区。(4)采用"地理探测器",基于采样点的青蒿素含量和生态环境因子指标,同时对连续型的定量数据、非连续型的定性数据进行分析,结果显示:日照、气温、降水量是影响青蒿素含量的主要因素。
Geo-herbals are preferred by long-term clinical application of Chinese medicine,they are produced in a specific area and affected by the specific production and processing methods. Geo-herbals have a high reputation,compared with other regions produced by the same kind of herbs with good quality,efficacy and stable quality characteristics. Geo-herbal is a unique concept that has been formed by the history of Chinese civilization for thousands of years and the history of Chinese medicine. According to the definition of geo-herbal,it can be seen that there are some differences in the quality and efficacy of the same kind of medicinal herbs in different regions,and there is some similarity in the specific area. In this study,the spatial distribution characteristics of artemisinin in Artemisia annua were analyzed by spatial statistical analysis.(1)The spatial autocorrelation of artemisinin content was analyzed by " I coefficient".The results showed that the content of artemisinin in each province was significant and positive spatial autocorrelation. The content of artemisinin in each province was not randomly distributed,but with a clear spatial aggregation characteristics.(2)The spatial variability of artemisinin content was analyzed by " G statistic". The results showed that the area with high content of artemisinin was distributed in the southwest region,and the content of artemisinin was concentrated in the space,which tends to accumulate at high value. The content of artemisinin in Tianjin and Liaoning province is low,and it tends to accumulate at low value,while the content of artemisinin in other provinces is the transition zone of high and low value.(3)Based on the index of artemisinin in each province,the spatial correlation of artemisinin content in each region was analyzed by " moran scatter plot". The results showed that the content of artemisinin in nine provinces such as Guangxi and Chongqing belonged to high value gathering area.(4)Based on the artemisinin content and ecological environment factor of sampling point,the " geophysical detector" was used to analyze the continuous quantitative data and discontinuous qualitative data. The results showed that the sunshine,temperature and precipitation were the main factors affecting the content of artemisinin.

关键词(KeyWords): 空间统计分析;黄花蒿;青蒿素;空间分布特征
spatial statistical analysis;Artemisia annua;artemisinin;spatial distribution characteristics

Abstract:

Keywords:

基金项目(Foundation): 中央本级重大增减支项目(2060302);; 科技基础性工作专项(2013FY114500);; 中医药全国性专项(ZZYZK2013-科技司A-004)

作者(Author): 张小波;郭兰萍;邱智东;曲晓波;王慧;景志贤;黄璐琦;
ZHANG Xiao-bo;GUO Lan-ping;QIU Zhi-dong;QU Xiao-bo;WANG Hui;JING Zhi-xian;HUANG Lu-qi;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medical,China Academy of Chinese Medical Sciences;College of Pharmacy,Changchun University of Chinese Medicine;

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DOI: 10.19540/j.cnki.cjcmm.2017.0168

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