巩仔鹏;林朝展;韩立炜;
GONG Zi-peng;LIN Chao-zhan;HAN Li-wei;Department of Health Science,National Natural Science Foundation of China;Provincial Key Laboratory of Pharmaceutics in Guizhou,State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and Traditional Chinese Medicine,School of Pharmacy,Guizhou Medical University;School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine;

• 1:国家自然科学基金委员会医学科学部
• 2:贵州医科大学药学院贵州省药物制剂重点实验室省部共建药用植物功效与利用国家重点实验室民族药与中药开发应用教育部工程研究中心
• 3:广州中医药大学中药学院

摘要(Abstract)：

中药药代动力学是研究中药复杂成分体内吸收、分布、代谢和排泄动态变化规律的一门学科,是阐明中药药效物质基础、作用特点、组方机制等方面的重要手段。但由于中药是多成分、多途径、多靶点且药效物质基础不明的多维复杂体系,使得中药药代动力学的研究成为中药领域的难题。随着新理论、新方法和新技术的不断涌现,中药药代动力学研究虽然得到快速发展,但从目前国家自然科学基金申请情况来看,中药药代动力学研究方向的申请项目仍存在一些问题。因此,该文从近五年(2016—2020年)国家自然科学基金资助项目简要分析中药药代动力学研究现状,主要包括中药药代动力学项目的申请和资助情况、主要研究内容,并重点分析研究热点、难点及不足之处,以期为从事中药药代动力学研究的科研人员提供一定的借鉴和参考。
The pharmacokinetics of traditional Chinese medicine is a subject that studies the dynamic changes of the absorption, distribution, metabolism and excretion of complex components of traditional Chinese medicine, which is an important method for elucidating the pharmacodynamic material basis, action characteristics, and compatibility mechanisms of traditional Chinese medicine. However, given on the fact that traditional Chinese medicine is a multi-dimensional and complex system with multiple components, multiple pathways, multiple targets, and an unclear pharmacodynamic material basis, the research on the pharmacokinetics of traditio-nal Chinese medicine has become a scientific and technological problem. Although the pharmacokinetics of traditional Chinese medicine has achieved remarkable development with the emergence of new theories, methods and technologies, there are still some problems in the application of the research direction of the pharmacokinetics of traditional Chinese medicine judging from the current application of the National Natural Science Foundation of China. Therefore, this article discussed the current research status on pharmacokinetics of traditional Chinese medicines by analyzing the projects funded by the National Natural Science Foundation of China in the past 5 years from 2016 to 2020, mainly including the application and funding analysis, main research contents of the projects in pharmacokinetics of traditional Chinese medicines. And the research hotspots, difficulties and deficiencies were focused in order to provide certain reference for researchers engaged in pharmacokinetics of traditional Chinese medicine.

关键词(KeyWords)： 国家自然科学基金;中药药代动力学;项目申请;研究现状
National Natural Science Foundation of China;pharmacokinetics of traditional Chinese medicine;project application;research status

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 巩仔鹏;林朝展;韩立炜;
GONG Zi-peng;LIN Chao-zhan;HAN Li-wei;Department of Health Science,National Natural Science Foundation of China;Provincial Key Laboratory of Pharmaceutics in Guizhou,State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and Traditional Chinese Medicine,School of Pharmacy,Guizhou Medical University;School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20210122.502

参考文献(References)：

• [1] 刘昌孝.中药药代动力学研究的难点和热点[J].药学学报,2005,40(5):395.
• [2] 汪小莉,刘晓,韩燕全,等.中药药效物质基础主要研究方法概述[J].中草药,2018,49(4):941.
• [3] 吕莉,孙慧君,韩国柱.中药药代动力学的研究进展[J].药学学报,2013,48(6):824.
• [4] 李晓宇,郝海平,王广基,等.三七总皂苷多效应成分整合药代动力学研究[J].中国天然药物,2008,6(5):377.
• [5] 巩仔鹏,陈颖,张瑞杰,等.疾病状态下的中药药代动力学研究进展[J].中国中药杂志,2015,40(2):169.
• [6] TEMPLETON I E,JONES N S,MUSIB L.Pediatric dose selection and utility of PBPK in determining dose[J].AAPS J,2018,20(2):31.
• [7] 国家药典委员会.中华人民共和国药典.一部[S].北京:中国医药科技出版社,2020.
• [8] COLLINS S L,PATTERSON A D.The gut microbiome:an orchestrator of xenobiotic metabolism [J].Acta Pharm Sin B,2020,10(1):19.
• [9] XU J,CHEN H B,LI S L.Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota [J].Med Res Rev,2017,37(5):1140.
• [10] CHEN J J,HE S R,FANG L,et al.Age-specific differential changes on gut microbiota composition in patients with major depressive disorder [J].Aging,2020,12(3):2764.
• [11] LIU R T,ROWAN-NASH A D,SHEEHAN A E,et al.Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults [J].Brain Behav Immun,2020,88:308.
• [12] HAN Y,SUN H,ZHANG A H,et al.Chinmedomics,a new strategy for evaluating the therapeutic efficacy of herbal medicines[J].Pharmacol Ther,2020,216(S1):107680.
• [13] 李川.中药多成分药代动力学研究:思路与方法[J].中国中药杂志,2017,42(4):607.
• [14] 谭兰芳,陈超,樊旭蕾,等.基于PK-PD模型评价脑脉通保护神经细胞的药效物质研究[J].中国中药杂志,2019,44(12):2588.
• [15] 陈光玮,田彦芳,万海同,等.麻黄汤有效组分对发热大鼠的解热作用及与药动学相关性研究[J].中国中药杂志,2020,45(3):655.
• [16] 倪苹,张经纬,刘嘉莉,等.细胞药代动力学研究进展[J].药学进展,2014,38(12):881.
• [17] 梁未雯.灯盏细辛注射液对脑缺血再灌注模型大鼠的PK-PD相关性研究[D].成都:成都中医药大学,2016:69.
• [18] 高方圆,袁伯俊,马秀娟,等.中药毒代动力学研究进展[J].中国新药杂志,2015,24(21):2448.
• [19] 郝海平,郑超湳,王广基.多组分、多靶点中药整体药代动力学研究的思考与探索[J].药学学报,2009,44(3):270.