中国中药杂志

2021, v.46(10) 2594-2600

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基于数据挖掘中药治疗溃疡性结肠炎的用药规律分析
Data mining of drug use rules based on traditional Chinese medicine treatment of ulcerative colitis

贾媛;王真真;李秀敏;苗明三;
JIA Yuan;WANG Zhen-zhen;LI Xiu-min;MIAO Ming-san;School of Pharmacy, Henan University of Chinese Medicine;

摘要(Abstract):

探讨中医治疗溃疡性结肠炎的用药规律,为临床治疗提供一定参考,以中国知网(CNKI)为数据来源,以"溃疡性结肠炎+中药"进行全文搜索,选取2000—2020年公开发表的文献,按照纳入与排除标准筛选临床上治疗溃疡性结肠炎的药方,利用Excel 2013,Clementine 12.0,IBM SPSS Statistics 25.0统计软件,进行统计处理和关联规则分析。共检索到3 432篇相关文献,按照标准筛选得到177首中药方剂,包括口服方93首,灌肠方84首。其中中药口服的高频药物有甘草、白术、黄连、木香、白芍,以补虚药、清热药、理气药为主;灌肠的高频药物有白及、黄连、地榆、黄柏、苦参,以清热药、止血药、补虚药为主。口服与灌肠药性均以温、寒、微寒为主,药味集中在苦、甘,涉及脾、胃、肺、大肠经。聚类分析中口服药和灌肠药均分为5类。因此治疗溃疡性结肠炎口服常选用补虚药、清热药、理气药,灌肠常选用清热药、止血药、补虚药,在此基础上分别配伍利水渗湿药和收涩药。
To explore the drug use rules of traditional Chinese medicine(TCM) in the treatment of ulcerative colitis, and to provide some references for clinical treatment. The full-text search of "ulcerative colitis+TCM" was conducted based on CNKI. The literatures published from 2000 to 2020 were selected, and the clinical prescriptions for ulcerative colitis were selected according to the inclusion and exclusion criteria. The statistical processing and association rule analysis were carried out with use of Excel 2013, Clementine 12.0 and IBM SPSS Statistics 25.0 statistical software. A total of 177 prescriptions were obtained after retrieval of 3 432 relevant literatures, including 93 oral prescriptions and 84 enema prescriptions. Among them, Glycyrrhizae Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma, Coptidis Rhizoma, Aucklandiae Radix and Paeoniae Radix Alba were the most frequently used drugs in oral administration, with the functions of tonifying, heat clearing and Qi regulating. The drugs with high frequency in enema included Bletillae Rhizoma, Coptidis Rhizoma, Sanguisorbae Radix, Phellodendri Chinensis Cortex and Sophorae Flavescentis Radix, with the functions of heat clearing, blood stopping and tonifying. Both oral and enema means of drugs were mainly of warm, cold and slightly cold properties, and bitter and sweet flavors, involving spleen, stomach, lung and large intestine. In cluster analysis, oral and enema drugs were divi-ded into 5 groups. Accordingly, in the treatment of ulcerative colitis, tonifying medicine, heat clearing medicine and Qi regulating medicine are often used for oral administration and heat clearing medicine, hemostatic medicine and tonifying medicine are often used for enema administration. On this basis, they are combined with diuretic drugs and astringent drugs respectively.

关键词(KeyWords): 溃疡性结肠炎;用药规律;口服;灌肠
ulcerative colitis;drug use rule;oral administration;enema

Abstract:

Keywords:

基金项目(Foundation): 国家国际合作基地项目(2016-65);; 河南省杰出外籍科学家工作室(GZS2019006);; 中原学者项目(162101510003)

作者(Authors): 贾媛;王真真;李秀敏;苗明三;
JIA Yuan;WANG Zhen-zhen;LI Xiu-min;MIAO Ming-san;School of Pharmacy, Henan University of Chinese Medicine;

DOI: 10.19540/j.cnki.cjcmm.20200911.501

参考文献(References):

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