中国中药杂志

2009, v.34(14) 1848-1851

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丹参毛状根对大鼠离体心脏缺血再灌注损伤的保护作用
Protection on myocardial ischemia and reperfusion injury by Salvia miltiorrhiza hairy root in isolated Langendorff rat hearts

王岚;吕冬梅;梁日欣;黄璐琦;袁媛;
WANG Lan,LV Dongmei,LIANG Rixing,HUANG Luqi,YUAN Yuan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Scinece,Beijing 100700)

摘要(Abstract):

目的:观察丹参毛状根对离体大鼠心肌缺血再灌注损伤的保护作用。方法:采用Langendorff离体心脏恒压灌流方法,以0.5 mL.min-1的灌流速度,生药质量浓度分别为14,28,56 mg.L-1的丹参毛状根,与k-H灌流液同时灌流心脏10min,然后全心停灌30 min,复灌60 min。结果:离体实验发现,丹参毛状根能够增加冠脉流量,不但降低心律失常的发生率,而且推迟心律失常的发生时间,缩短持续时间和恢复时间,减低LDH,MDA的释放,增加SOD活性。结论:丹参毛状根对大鼠离体心脏缺血再灌注损伤具有一定的保护作用;与丹参药材相比无显著性差异。
Objective:Protection by Salvia miltiorrhiza hairy root on myocardial ischemia and reperfusion injury in isolated Langendorff rat hearts was observed.Method: Isolated rat hearts were perfused with 14,28,56 mg·L-1 for 10 min followed by a 10 min washout period before the induction of 30 min normothermic global ischemia and 60 min of reperfusion.Result: Our results showed that S.miltiorrhiza hairy root reduced the incidence of reperfusion-induced VF and VT and delayed the onset time of VF and VT.The increased aortic flow and content of SOD with decreased release of LDH and MDA were found.Conclusion: Our results show that S.miltiorrhiza hairy root can prevent postischmic abnormalities in reperfusion arrhythmias,aortic flow and myocardium metabolism,which was similar to actions of S.miltiorrhiza.

关键词(KeyWords): 丹参毛状根;缺血再灌注损伤;丹参
Salvia miltiorrhiza hairy root;ischemia and reperfusion injury;Salvia miltiorrhiza

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基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2006CB504700);; 国家高技术研究发展计划(863)项目(2007AA02Z104)

作者(Author): 王岚;吕冬梅;梁日欣;黄璐琦;袁媛;
WANG Lan,LV Dongmei,LIANG Rixing,HUANG Luqi,YUAN Yuan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Scinece,Beijing 100700)

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