中国中药杂志

2011, v.36(19) 2693-2696

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两面针提取物抗胃癌谱-效关系研究
Study on chromatography-efficacy relation of Zanthoxylum nitidum on gastric cancer cells

申庆荣;黄慧学;王宏虹;曹利娟;冯看;叶月华;刘华钢;
SHEN Qingrong1,HUANG Huixue2,WANG Honghong3,CAO Lijuan4,FENG Kan5,YE Yuehua4,LIU Huagang6*(1.The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China; 2.Guangxi Traditional Chinese Medical University,Nanning 530001,China; 3.Maternal and Child Health Hospital of Liuzhou,Liuzhou 545001,China; 4.Guangxi Food and Drug Administration,Nanning 530021,China; 5.Liuzhou Center for Disease Control and Prevention,Liuzhou 545007,China; 6.Guangxi Medical University,Nanning 530021,China)

摘要(Abstract):

目的:探讨两面针提取物抗胃癌谱-效关系的建立方法。方法:用MTT和HPLC分别测定两面针肿瘤抑制率和指纹峰数据,再用适合的统计学方法建立谱-效关系。结果:用逐步后退法建立了两面针抗胃癌谱-效关系式。结论:该关系式具有统计学意义和实际意义,因此具有一定的参考价值。
Objective: To develop a method for elucidating "chromatography-efficacy" relation of the extract of Zanthoxylum nitidum on the gastric cancer cells.Method: After obtaining the tumor inhibition rate and fingerprint peak data through MTT and HPLC,"chromatography-efficacy" relation was established by an appropriate statistical method.Result: The gastric cancer "chromatography-efficacy" relation of Z.nitidum was established by step-back technique.Conclusion: The "chromatography-efficacy" relation has statistically significant and practical significance,so it has reference value in some way.

关键词(KeyWords): 两面针;MTT;高效液相色谱法;逐步后退法;谱-效关系
Zanthoxylum nitidum;MTT;HPLC;step-back technique;"chromatography-efficacy" relation

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基金项目(Foundation): 国家自然科学基金地区科学基金项目(30760302)

作者(Author): 申庆荣;黄慧学;王宏虹;曹利娟;冯看;叶月华;刘华钢;
SHEN Qingrong1,HUANG Huixue2,WANG Honghong3,CAO Lijuan4,FENG Kan5,YE Yuehua4,LIU Huagang6*(1.The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China; 2.Guangxi Traditional Chinese Medical University,Nanning 530001,China; 3.Maternal and Child Health Hospital of Liuzhou,Liuzhou 545001,China; 4.Guangxi Food and Drug Administration,Nanning 530021,China; 5.Liuzhou Center for Disease Control and Prevention,Liuzhou 545007,China; 6.Guangxi Medical University,Nanning 530021,China)

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