中国中药杂志

2021, v.46(04) 801-809

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经典名方桃红四物汤的物质基准量值传递分析
Analysis on quality value transfer of substance benchmarks of Taohong Siwu Decoction

杨艳玲;刘彩凤;黄嘉怡;杨海菊;钟宛凌;李花花;杜守颖;白洁;
YANG Yan-ling;LIU Cai-feng;HUANG Jia-yi;YANG Hai-ju;ZHONG Wan-ling;LI Hua-hua;DU Shou-ying;BAI Jie;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

摘要(Abstract):

制备15批桃红四物汤物质基准,建立物质基准特征图谱的检测方法,明确其特征图谱的相似度范围、峰归属,结合出膏率范围,指标性成分羟基红花黄色素A、阿魏酸和芍药苷的含量范围及转移率范围,进行量值传递分析,阐明桃红四物汤物质基准的关键质量属性。结果表明,15批桃红四物汤物质基准特征图谱相似度良好(均>0.9);进一步汇总特征峰信息可知,全方共13个特征峰,分别归属为酒白芍3个特征峰、酒洗红花7个特征峰、酒洗当归及川芎3个特征峰;15批物质基准的出膏率控制在33.11%~40.62%;指标性成分羟基红花黄色素A的质量分数为0.129%~0.203%,平均转移率为16.596%±0.669%;阿魏酸的质量分数为0.043%~0.055%,平均转移率为20.489%±1.772%;芍药苷的质量分数为0.676%~0.943%,平均转移率为29.112%±3.273%。采用特征图谱、出膏率及指标性成分含量测定相结合的模式,对经典名方桃红四物汤物质基准的量值传递过程进行分析,建立的物质基准质量评价方法稳定可行,可为经典名方桃红四物汤的质量控制及相关制剂的后续开发提供依据。
By preparing 15 batches of substance benchmarks of Taohong Siwu Decoction, the methodology of the characteristic spectrums of substance benchmarks was established. The paste-forming rate range, the contents and the transfer rate range of the index components, hydroxy safflower yellow A, ferulic acid and paeoniflorin, the characteristic peaks and the similarity range of the characteristic spectrums of Taohong Siwu Decoction were determined to define key quality attributes of substance benchmarks of Taohong Siwu Decoction.In the 15 batches of substance benchmarks of Taohong Siwu Decoction, the similarity of characteristic spectrums was higher than 0.9. Furthermore, based on summarization of the characteristic peak information, there were 13 characteristic peaks in the whole decoction. Baishao had three characteristic peaks, Honghua had seven characteristic peaks, and Chuanxiong and Danggui had three characteristic peaks. The paste-forming rate of the 15 batches of substance benchmarks was controlled at 33.11%-40.62%. The content of hydroxy safflower yellow A was 0.129%-0.203%, with the average transfer rate of 16.596%±0.669%.The content of ferulic acid was 0.043%-0.055%, with the average transfer rate of 20.489%±1.772%.The content of paeoniflorin was 0.676%-0.943%, with the average transfer rate of 29.112%±3.273%.The quality value transfer of substance benchmarks of classical prescription Taohong Siwu Decoction was analyzed by the combination of characteristic spectrums, paste-forming rate and the content of index components. The established substance benchmark quality evaluation method was stable and feasible, and could provide a basis for quality control and subsequent development of relevant preparations of Taohong Siwu Decoction.

关键词(KeyWords): 经典名方;桃红四物汤;物质基准;特征图谱;量值传递
classical prescription;Taohong Siwu Decoction;substance benchmarks;characteristic spectrum;quality value transfer

Abstract:

Keywords:

基金项目(Foundation): 中央高校基本科研业务费专项(2020-JYB-ZDGG-032)

作者(Author): 杨艳玲;刘彩凤;黄嘉怡;杨海菊;钟宛凌;李花花;杜守颖;白洁;
YANG Yan-ling;LIU Cai-feng;HUANG Jia-yi;YANG Hai-ju;ZHONG Wan-ling;LI Hua-hua;DU Shou-ying;BAI Jie;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

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DOI: 10.19540/j.cnki.cjcmm.20200925.301

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