中国中药杂志

2016, v.41(12) 2273-2279

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多穗金粟兰的化学成分研究
Study on chemical constituents from Chloranthus multistachys

林凤祥;李宏焘;张丽;张珊珊;张琪;陈怀远;罗永明;
LIN Feng-xiang;LI Hong-tao;ZHANG Li;ZHANG Shan-shan;ZHANG Qi;CHEN Huai-yuan;LUO Yong-ming;School of Pharmacy,Jiangxi University of Traditional Chinese Medicine;

摘要(Abstract):

对金粟兰属植物多穗金粟兰Chloranthus multistachys的化学成分进行研究。利用反复硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱和制备液相色谱等方法对其进行提取、分离和纯化,并利用核磁共振(NMR)、质谱等现代波谱技术对所得化合物的结构进行鉴定。从多穗金粟兰根的氯仿萃取部位和乙酸乙酯萃取部位分离得到了19个化合物,分别鉴定为zederone epoxide(1),chlomultin C(2),curcolonol(3),sarcaglaboside A(4),zedoarofuran(5),(1E,4Z)-8-hydroxy-6-oxogermacra-1(10),4,7(11)-trieno-12,8-lactone(6),chloranoside A(7),没药素A(8),(8α)-6,8-dihydroxycadina-7(11),10(15)-dien-12-oic acid-γ-lactone(9),党参内酯(10),粗叶木内酯A(11),12,15-epoxy-5αH,9βH-labda-8(17),13-dien-19-oicacid(12),12R,15-dihydroxylabda-8(17),13E-dien-19-oic acid(13),反式桂皮酸酰对羟基苯乙胺(14),反式-N-p-香豆酰酪胺(15),邻苯二甲酸二丁酯(16),2'-羟基-4,4',6'-三甲氧基查耳酮(17),岩白菜素(18)和enedione(19)。化合物1,2,4,7~10和12~19为首次从多穗金粟兰中分离得到,其中化合物14~19为首次从金粟兰属植物中分离得到。
To investigate the chemical constituents from the shoots of Chloranthus multistachys. All compounds wereisolated by using a combination of various chromatographic techniques including silica gel,ODS,Sephadex LH-20,reversed-phase HPLC,and other methods. Their structures were elucidated by the nuclear magnetic resonance( NMR),mass spectrometry,and other modernspectroscopies. As a result,19 compounds were isolated from the shoots of C. multistachys and identified as zederoneepoxide( 1),chlomultin C( 2),curcolonol( 3),sarcaglaboside A( 4),zedoarofuran( 5),( 1E,4Z)-8-hydroxy-6-oxogermacra-1( 10),4,7( 11)-trieno-12,8-lactone( 6),chloranoside A( 7),istanbulin A( 8),( 8α)-6,8-dihydroxycadina-7( 11),10( 15)-dien-12-oicacid-γ-lactone( 9),codonolactone( 10),lasianthuslactone A( 11),12,15-epoxy-5αH,9βH-labda-8( 17),13-dien-19-oicacid( 12),12 R,15-dihydroxylabda-8( 17),13E-dien-19-oicacid( 13),N-transcinnamoyltyramine( 14),trans-N-p-coumaroyltyramine( 15),dibutyl phthalate( 16),flavokawain A( 17),bergenin( 18),and enedione( 19). Compounds 1,2,4,7-10,12-19 were isolated from C. multistachys for the first time and compounds 14-19 were obtained from the genus Chloranthus for the first time.

关键词(KeyWords): 多穗金粟兰;金粟兰属;化学成分
Chloranthus multistachys;Chloranthus;chemical constituents

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(21262019);; 江西省高等学校科技落地计划项目(KJLD13064)

作者(Author): 林凤祥;李宏焘;张丽;张珊珊;张琪;陈怀远;罗永明;
LIN Feng-xiang;LI Hong-tao;ZHANG Li;ZHANG Shan-shan;ZHANG Qi;CHEN Huai-yuan;LUO Yong-ming;School of Pharmacy,Jiangxi University of Traditional Chinese Medicine;

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