中国中药杂志

2010, v.35(17) 2346-2349

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槐花制炭后新止血成分的药理研究
Pharmacology experimental study of new hematischesis compounds after Flos Sophorae carbonized

赵雍;郭静;刘婷;李春英;曹春雨;易艳;郝然;李娆娆;
ZHAO Yong,GUO Jing,LIU Ting,LI Chunying,CAO Chunyu,YI Yan,HAO Ran,LI Raorao (Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

摘要(Abstract):

目的:观察槐花制炭前后饮片、提取物止血作用的改变,以及主要成分、特征性成分的止血作用强度,探索槐花制炭后新的止血成分。方法:以出血时间(BT)和血浆复钙时间(RT)为止血作用的特异性指标,观察槐花生品、炭品,炭品的特征性提取物A和B(SCE A和B)及主要成分灌胃给药后对正常大鼠止血作用的影响,分析其制炭后可能存在的新止血成分。结果:槐花生品,炭品能显著缩短正常大鼠BT和RT,其中炭品作用强于生品。SCE A和SCE B均能显著缩短正常大鼠BT和RT,其中SCE B作用优于SCE A。进一步研究SCE B中提取得到的成分1(槐树皂苷Ⅰ)和2(异鼠李素-3-O-芸香糖苷)及其主要成分(芦丁、鞣质),均能显著缩短正常大鼠BT和RT,其中成分2的作用最优。结论:槐花生品,炭品及槐花制炭后2种提取物和上述4种成分止血作用均显著增加,其中成分2作用显著,提示该成分可能是槐花炭发挥止血作用的新有效成分,也表明槐花炒炭后止血作用增加应是多种成分的协同结果。
Objective: To search new effective compounds,the different hemostatic effects of Flos Sophorae,Flos Sophorae Carbonisatus and principal constituent were observed.Method: Using the bleeding time(BT) and the recalcification time(RT) as the specificity indicators for the hematischesis function,the hemostatic effects of the following were observed.Flos Sophorae,Flos Sophorae Carbonisatus,characteristic value extraction thing A and B(SCE A and B) and the principal constituent after orally administered in normal rats in order to analyze the new hemostatic compounds.Result: Flos Sophorae,and Flos Sophorae Carbonisatus can obviously reduce BT and RT in rats,in which the effect of Carbonisatus is stronger than the crude.Otherwhile,SCE A and SCE B can also obviously reduce BT and RT in rats,in which the effects of SCE B surpassed those of SCE A.Furthermore,two characteristic compounds extracted from SCE B(kaikasaponin I called compound 1 and isorhamnetin-3-O-rutinoside named called 2) and other nominated principal constituents(rutin,tannin),can obviously shorten BT and RT in rats,among which compound 2 is most superior.Conclusion: The Flos Sophorae,Flos Sophorae Carbonisatus and their character compounds can shorten the BT and RT in rats.The compound 2 from SCE B has the most superior effect.Study showed that compound 2 should be the new hemostatic compounds after Flos Sophorae carbonized.The results also indicated that the increase of hemostatic effect after Flos Sophorae carbonized should be related with the coordination of various kinds of ingredient.

关键词(KeyWords): 槐花炭;止血作用;出血时间;血浆复钙时间
Flos Sophorae Carbonisatus;hemostatic effect;bleeding time(BT);recalcification time(RT)

Abstract:

Keywords:

基金项目(Foundation): 北京市自然科学基金项目(7062050)

作者(Author): 赵雍;郭静;刘婷;李春英;曹春雨;易艳;郝然;李娆娆;
ZHAO Yong,GUO Jing,LIU Ting,LI Chunying,CAO Chunyu,YI Yan,HAO Ran,LI Raorao (Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

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