中国中药杂志

2020, v.45(16) 3770-3775

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

中药靶向ERα/ERβ的阴阳调和机制及其在绝经期综合征治疗中的应用
Mechanism of traditional Chinese medicine balancing Yin-Yang by targeting ERα/ERβ and its application in treatment of menopausal syndrome

赵丕文;王燕霞;牛建昭;
ZHAO Pi-wen;WANG Yan-xia;NIU Jian-zhao;School of Life Science, Beijing University of Chinese Medicine;Dongzhimen Hospital, Beijing University of Chinese Medicine;School of Chinese Medicine, Beijing University of Chinese Medicine;

摘要(Abstract):

阴阳的协调统一是人体正常生命活动运行的基础。女性伴随着年龄的增长和机体的衰老,绝经前后将出现绝经期综合征,在生殖系统有显著功能变化之外,集中表现在骨骼、神经、心血管系统等雌激素靶向位点阴阳失衡所导致的病理变化。其发生原因除雌激素分泌水平下降外,另一个很重要的诱因是靶器官对雌激素应答反应的变化,即由于靶细胞雌激素受体(estrogen receptor, ER)α和β亚型介导生物学效应的趋势常有所差异甚至相互拮抗,ERα和ERβ表达水平和比例的改变也是导致靶器官雌激素效应异常、机体阴阳失衡的重要原因。因此,药物发挥疗效的机制一方面是其所具有的ER介导的雌激素样效应,另一方面即是药物对靶细胞ER亚型表达的调节功能及由此引发的对靶器官乃至机体阴阳状态的调控作用,从而进一步引发靶细胞对雌激素或雌激素样成分应答反应的变化,发挥疗效。该文将从雌激素及其作用机制、ER在中药发挥雌激素样效应中的作用、中药在绝经期综合征治疗中以ER亚型介导与调节功能为基础的阴阳调衡机制等方面进行综述,为阐明妇科中药在雌激素主要靶向组织调和阴阳、发挥临床疗效的药理机制提供参考。
The coordination and unification of Yin and Yang are the basis of normal human life activities. Along with the age growth and aging of the body, women will suffer from menopausal syndrome during menopause. In addition to the significant changes in the genital system, there are also pathological manifestations in estrogen target points including bone, nerve and cardiovascular systems, due to the imbalance of Yin and Yang. Besides the insufficiency of estrogen, the main cause of menopausal syndrome is the changes in the response of target organs to estrogen. In other words, the biological effects mediated by estrogen receptor(ER) alpha and beta subtypes in target cells are often different or even opposite; the changes of expression level and ratio of ERα and ERβ are also important causes for the abnormal estrogenic effects in target organs and the imbalance of Yin and Yang of the body. Therefore, on one hand, the therapeutic mechanism of drugs is ER-mediated estrogenic effect. On the other hand, the drugs have a regulatory effect on ER subtype expression in target cells and Yin-Yang state in target organs and even organisms, so as to cause further changes in the response of target cells to estrogen or estrogenic components, and exert its therapeutic effects. This paper reviews the pharmacological mechanism of gynecological traditional Chinese medicine in harmonizing Yin and Yang in estrogen-positive target cells and the clinical efficacy in the following aspects, including estrogen and its mechanism, the estrogenic effect of ER in traditional Chinese medicine and the mechanism of ER subtype in balancing Yin and Yang and mediating and regulating the main target tissues in menopausal syndrome treatment.

关键词(KeyWords): 中药;绝经期综合征;ERα/ERβ;阴阳调和
traditional Chinese medicine;menopausal syndrome;estrogen receptor alpha/estrogen receptor beta;balancing Yin-Yang

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81673764);; 教育部&国家外国专家局项目(B07007)

作者(Author): 赵丕文;王燕霞;牛建昭;
ZHAO Pi-wen;WANG Yan-xia;NIU Jian-zhao;School of Life Science, Beijing University of Chinese Medicine;Dongzhimen Hospital, Beijing University of Chinese Medicine;School of Chinese Medicine, Beijing University of Chinese Medicine;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享