中国中药杂志

2013, v.38(12) 1856-1859

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银杏内酯组分结构优化实验研究
Experimental study on structure optimization of ginkgolide components

刘丹;贾晓斌;萧伟;
LIU Dan1,2,JIA Xiao-bin1,2*,XIAO Wei3*(1.Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China; 2.School of Pharmacy,Jiangsu University,Zhenjiang 212013,China; 3.State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China)

摘要(Abstract):

通过大量文献检索,发现当前药学工作者对"中药组分"的概念出现各家各说的现象。那么中药组分到底是什么?笔者认为"中药组分"应该是药效物质和作用机制相对清楚,具有一定纯度含量且内部结构明确的中药优化组分。该试验通过对银杏内酯组分中4个报道成分进行配比,结合体内外药效药理实验,从而初步确定银杏内酯优化组分结构。该实验设计可以为今后中药组分优化和配比结构确定提供研究思路及依据。
Having searched a large number of literatures,the author found different concepts of traditional Chinese medicine components among pharmacists.Then,what are traditional Chinese medicine components? The author thinks that traditional Chinese medicine components shall be optimized traditional Chinese medicine components with relatively clear efficient substances,action mechanisms,specific purity and definite internal structure.This experiment preliminarily determined optimized component structures of ginkgolides by comparing the four reported constituents in in vivo and in vitro pharmacodynamic and pharmacological experiments.The experimental design could provide ideas and basis for optimizing traditional Chinese medicine components and determining their matching structures.

关键词(KeyWords): 中药优化组分;中药物质基础;配比;药理药效实验
optimized traditional Chinese medicine component;material basis of traditional Chinese medicine;matching;pharmacodynamic and pharmacological experiment

Abstract:

Keywords:

基金项目(Foundation): 国家“十一五”科技支撑计划项目(2008BAI51B03);; 制剂过程新技术国家重点研究项目(SKL2010Z0303);; 江苏省中医药局中医药科技技术研究专项(LZ09061)

作者(Author): 刘丹;贾晓斌;萧伟;
LIU Dan1,2,JIA Xiao-bin1,2*,XIAO Wei3*(1.Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China; 2.School of Pharmacy,Jiangsu University,Zhenjiang 212013,China; 3.State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China)

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