中国中药杂志

2016, v.41(08) 1541-1545

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离体大鼠肠道菌群对类叶升麻苷代谢的研究
Effect of rat intestinal flora in vitro on metabolites of acteoside

张文秀;杨彪;胡玉梅;孟兆青;黄文哲;王振中;萧伟;
ZHANG Wen-xiu;YANG Biao;HU Yu-mei;MENG Zhao-qing;HUANG Wen-zhe;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;China Pharmaceutical University;

摘要(Abstract):

在离体培养的大鼠肠道菌群中加入类叶升麻苷进行厌氧孵育。采用HPLC监测类叶升麻苷在不同孵育时间点的变化,同时运用HPLC-Q-TOF-MS鉴定类叶升麻苷的代谢产物。结果表明离体的大鼠肠道菌群可以对类叶升麻苷进行代谢,代谢产物分别是3,4-二羟基苯乙醇、咖啡酸和3-(3'-羟苯基)丙酸。
Acteoside was used for anaerobic incubation with rat intestinal flora in vitro. HPLC was used to detect the changes of acteoside at different incubation time points and HPLC-Q-TOF-MS was used to identify the metabolites of acteoside. The results showed that acteoside could be metabolized by rat intestinal flora in vitro and the metabolites were 3,4-dihydroxyphenyl acid,caffeic acid and3-( 3'-hydroxyphenyl) propionic acid.

关键词(KeyWords): 类叶升麻苷;肠道菌群;代谢产物;液质联用
acteoside;intestinal flora;metabolites;LC-MS

Abstract:

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 张文秀;杨彪;胡玉梅;孟兆青;黄文哲;王振中;萧伟;
ZHANG Wen-xiu;YANG Biao;HU Yu-mei;MENG Zhao-qing;HUANG Wen-zhe;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;China Pharmaceutical University;

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