中国中药杂志

2021, v.46(20) 5201-5209

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血瘀证血小板改变及中医药作用研究进展
Research progress of change of platelet in blood stasis syndrome and effect of traditional Chinese medicine

王紫艳;李磊;刘建勋;孟红旭;苗兰;孙明谦;张业昊;
WANG Zi-yan;LI Lei;LIU Jian-xun;MENG Hong-xu;MIAO Lan;SUN Ming-qian;ZHANG Ye-hao;Beijing Key Laboratory of Chinese Materia Pharmacology, National Cardiouascular Disease Research Center of Tradtional Chinese Medicine, Institute of Basic Medical Sciences of Xiyuan hospital,China Academy of Chinese Medical Sciences;

摘要(Abstract):

中医血瘀证是指体内血液停滞或血运不畅,阻滞于经脉及脏腑内,以疼痛、肿块、出血、舌紫、脉涩等为主要表现的证候。心脑血管疾病是严重危害我国人民健康的重大慢性疾病,冠心病和脑卒中大部分为血瘀证。血小板被认为是参与血栓形成的必要因素之一,聚焦中医血瘀证的范畴,相关的心脑血管疾病的发生也与之息息相关,临床和实验室针对血小板活化聚集等功能的研究也被越来越广泛的重视,其目的在于治疗和预防中医血瘀证。该文在中医血瘀证的范围内,收集并分析了目前关于血瘀证血小板功能异常的研究、血瘀证生物学基础的研究以及活血化瘀方药对血瘀证血小板的作用等内容,旨为血瘀证血小板机制研究及其中医药防治通路靶点研究提供参考。
The traditional Chinese medicine(TCM) syndrome of blood stasis refers to blood stagnation in meridians and viscera, with the main symptoms of pain, mass, bleeding, purple tongue, and unsmooth pulse. Cardiovascular and cerebrovascular diseases are among the major chronic diseases seriously harming the health of the Chinese. Among the coronary heart disease and stroke patients, most demonstrate the blood stasis syndrome. Platelet is considered to be one of the necessary factors in thrombosis, which closely relates to the TCM syndrome of blood stasis and the occurrence of cardiovascular and cerebrovascular diseases. The clinical and laboratory research on platelet activation and aggregation has been paid more and more attention. Its purpose is to treat and prevent blood stasis syndrome. In this study, the authors analyzed the research on the dysfunctions of platelets in blood stasis syndrome, biological basis of TCM blood stasis syndrome, and the effect of blood-activating stasis-resolving prescriptions on platelets, aiming at providing a reference for exploring the mechanism of platelet intervention in the treatment of TCM blood stasis syndrome and the pathways and targets of Chinese medicine in the prevention and treatment of the syndrome.

关键词(KeyWords): 中医血瘀证;血小板;血小板异常活化;系统生物学;活血化瘀;中药单体成分
traditional Chinese medicine syndrome of blood stasis;platelet;platelet activation abnormality;systems biology;activating blood and resolving stasis;monomers of Chinese medicine

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(82030124);; 国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目

作者(Author): 王紫艳;李磊;刘建勋;孟红旭;苗兰;孙明谦;张业昊;
WANG Zi-yan;LI Lei;LIU Jian-xun;MENG Hong-xu;MIAO Lan;SUN Ming-qian;ZHANG Ye-hao;Beijing Key Laboratory of Chinese Materia Pharmacology, National Cardiouascular Disease Research Center of Tradtional Chinese Medicine, Institute of Basic Medical Sciences of Xiyuan hospital,China Academy of Chinese Medical Sciences;

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