中国中药杂志

2002, (09)

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广西藤茶总黄酮降血糖的实验研究
Experimental Studies of Hypoglycemic Action on Total Flavone of Ampelopsis grossedentata from Guangxi

钟正贤,覃洁萍,周桂芬,陈学芬
ZHONG Zheng xian, QIN Jie pin ,ZHOU Gui fen, CHEN Xue fen (1.Guangxi Institute of Traditional Medical and Pharma ceutical Sciences, Nanning 530022, Guangxi , China; 2.Guangxi College of Traditional Chinese Medicine, Nanning 530000, Guangxi , Chin

摘要(Abstract):

目的 :为了研究广西藤茶总黄酮 (GXTF)的降血糖作用 ,观察了GXTF对多种动物模型血糖水平的影响。方法 :采用四氧嘧啶所致糖尿病模型、肾上腺素和葡萄糖引起的高血糖小鼠模型 ,以及正常小鼠口服给药 ,测定各模型小鼠的血糖水平 ;并对GXTF进行了急性毒性试验。结果 :GXTF对四氧嘧啶所致糖尿病小鼠有较好的治疗作用 ,对肾上腺素、葡萄糖引起的高血糖小鼠也有明显的降血糖作用 ,但对正常小鼠血糖无明显影响。急性毒性试验表明 ,其最大灌胃量为 2 6 .0 g·kg-1。结论 :GXTF对多种动物模型具有较好的降血糖作用 ,且毒性很小。
Objective: To study hypoglycemic action of total flavone (GXTF) of Ampelopsis grossedentata from Guangxi by observing the effects of GXTF on blood glucose levels in many strain animal models. Method: The blood glucose levels in many strain animal models were determined after oral administration, with the models of diabetes induced by alloxan, of hyperglycemic mice induced by epinephrine and glucose, and normal mice. Result: GXTF had better therapeutical action on diabetes mice induced by alloxan, and could significantly lowered the blood glucose levels of hyperglycemic mice induced by epinephrine and glucose,but had no significant effects on blood glucose levels of normal mice. Acute toxicity test showed that the maximum oral dosage is 26.0g·kg -1 .Conclusion: GXTF has better hypoglycemic effect on many strain animal models and toxicity is vary small.

关键词(KeyWords): GXTF;降血糖;动物实验
GXTF; hypoglycemic action ;animal expeperiment

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基金项目(Foundation): 国家中医药管理局中医药科学技术研究基金资助项目 (国中医药科 0 0 0 1L(M ) ) ;; 广西青年科学基金资助项目 (桂科青0 0 0 70 2 5 )

作者(Author): 钟正贤,覃洁萍,周桂芬,陈学芬
ZHONG Zheng xian, QIN Jie pin ,ZHOU Gui fen, CHEN Xue fen (1.Guangxi Institute of Traditional Medical and Pharma ceutical Sciences, Nanning 530022, Guangxi , China; 2.Guangxi College of Traditional Chinese Medicine, Nanning 530000, Guangxi , Chin

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