中国中药杂志

2014, v.39(19) 3803-3807

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对照提取物用于当归药材质量控制的研究
Quality control of Angelica sinensis with standard reference extract

席骏钻;钱怡云;段金廒;严辉;赵玉洋;张洁;郭玲;钱大玮;
XI Jun-zuan;QIAN Yi-yun;DUAN Jin-ao;YAN Hui;ZHAO Yu-yang;ZHANG Jie;Guo Ling;QIAN Da-wei;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine;Gansu University of Traditional Chinese Medicine;

摘要(Abstract):

为提高当归药材的质量标准,解决部分对照品稀缺问题,进行了以对照提取物为对照的当归药材质量控制研究。采用色谱分离技术制备对照提取物,并对其中3个指标成分阿魏酸、洋川芎内酯I、洋川芎内酯H进行标定,建立了以对照提取物为对照的当归药材UPLC含量测定方法,并采用t检验对以对照提取物和对照品为对照的测定结果进行比较,结果基本一致,该方法可用于当归药材质量控制,且经济实用,本研究初步验证了其可行性。
To improve the quality standard of Angelica sinensis,solve the problem of lacking relevant reference substance,a new method-based on the standard reference extract( SRE) was applied to achieve the quality control of Angelica sinensis. SRE of Angelica sinensis was obtained by chromatographic separation technology. After calibration of three makers of the SRE,an UPLC analytical method was developed to determinate the contents of the makers. T-test was used for comparison of the determination results of two methods( reference substances and SRE as reference,respectively),and the results demonstrated that there is no significant difference between the two methods. The presented method is very convenient and practical,which can be used for the quality control of Angelica sinensis.

关键词(KeyWords): 当归;对照提取物;质量控制
Angelica sinensis;standard reference extract(SRE);quality control

Abstract:

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基金项目(Foundation): 中央本级重大增减支项目(20603020122,20603020201);; 中药材扶持资金项目[(2011)340]

作者(Author): 席骏钻;钱怡云;段金廒;严辉;赵玉洋;张洁;郭玲;钱大玮;
XI Jun-zuan;QIAN Yi-yun;DUAN Jin-ao;YAN Hui;ZHAO Yu-yang;ZHANG Jie;Guo Ling;QIAN Da-wei;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine;Gansu University of Traditional Chinese Medicine;

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