中国中药杂志

2021, v.46(04) 757-761

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基于中西医临床病症特点的结肠炎动物模型分析
Analysis of animal models of ulcerative colitis based on characteristics of clinical symptoms of traditional Chinese and Wes-tern medicine

王峥;贺红娟;李秀敏;苗明三;
WANG Zheng;HE Hong-juan;LI Xiu-min;MIAO Ming-san;Henan University of Chinese Medicine;

摘要(Abstract):

该文旨在为药物治疗结肠炎的研究提供良好的实验方法。基于结肠炎疾病的中医、西医临床病症特点,分析现有常用的结肠炎动物模型,总结目前结肠炎动物模型与临床病症的契合程度及优缺点。目前对结肠炎的研究主要采用免疫法、化学刺激法、复合法、基因模型等4类建模方法。已报道的结肠炎造模方法较多,但没有一种模型能反映结肠炎中西医临床病症特点。该文基于免疫法、化学刺激法、复合法、基因模型的特点、临床相关症状及优缺点做一综述,为后续研究结肠炎的防治提供可靠的动物模型。
This article aims to provide a good experimental method for the study of drug treatment of ulcerative colitis. According to the characteristics of ulcerative colitis′s clinical symptoms, common ulcerative colitis animal models were analyzed. Based on the characteristics of clinical symptoms of traditional Chinese medicine and Western medicine for ulcerative colitis disease, the existing commonly used animal models of ulcerative colitis were analyzed to summarize the current matching degree, advantages and disadvantages of the exi-sting animal models of ulcerative colitis and clinical symptoms. At present, studies on ulcerative colitis mainly adopt four types of induction modeling methods, such as immunization, chemical stimulation, compound method and gene model. There are many reported methods of colitis modeling, but no model can reflect the characteristics of clinical symptoms of ulcerative colitis treated with Western or Chinese medicine. This article summarizes the characteristics, clinically relevant symptoms and applicable scope of immunization, chemical stimulation, compound method, and gene model, so as to provide a reliable animal model for subsequent studies of prevention and treatment of colitis.

关键词(KeyWords): 结肠炎;动物模型;临床病症
ulcerative colitis;animal model;clinical symptoms

Abstract:

Keywords:

基金项目(Foundation): 国家国际合作基地项目(2016-65);; 河南省杰出外籍科学家工作室项目(GZS2019006);; 中原学者项目(162101510003)

作者(Author): 王峥;贺红娟;李秀敏;苗明三;
WANG Zheng;HE Hong-juan;LI Xiu-min;MIAO Ming-san;Henan University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200916.602

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