中国中药杂志

2014, v.39(11) 2097-2101

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三七皂苷类成分的蛋白质相互作用网络分析
Protein interaction network analysis of Panax notoginseng saponins

任真真;张燕玲;王星;王石峰;贺昱甦;翟晨曦;乔延江;
REN Zhen-zhen;ZHANG Yan-ling;WANG Xing;WANG Shi-feng;HE Yu-su;ZHAI Chen-xi;QIAO Yan-jiang;Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine;

摘要(Abstract):

三七皂苷类成分是三七发挥药效的活性部位,目前对其作用机制尚无系统的研究。该文构建了三七皂苷类成分的蛋白互作网络并对网络进行模块分析,通过模块的功能及包含的蛋白从分子水平上阐释三七皂苷类成分的作用机制。结果表明三七皂苷发挥药效主要与环磷酸腺苷代谢、血管伸缩、血液凝固、T细胞增殖与分化等生物过程相关。
Panax notoginseng(PN) is one of the commonly used clinical medicines for cardiovascular diseases and possesses a variety of pharmacological effects.P.notoginseng saponins(PNS) are the most important bioactive components in PN.The purpose of this study was to explain the mechanism of PNS on molecular network level.18 targets of the main medicinal ingredients of PNS were gained by virtual screening based on pharmacophores and data mining.A protein interaction network of PNS was constructed with 189nodes and 721 interactions.By a graph theoretic clustering algorithm Molecular Complex Detection(MCODE),14 modules were detected.Gene ontology(GO) enrichment analysis of the modules demonstrated that the roles of PNS played in cardiovascular disease related to multiple biological processes,which could represent the characteristics of troditional Chinese medicine(TCM) as a whole to regulate the disease.The results showed that the blood circulation and hemostasis efficacy of PN related with the biological processes such as positive regulation of cAMP metabolic and biosynthetic process,platelet activation and regulation of blood vessel size,regulation of T cell proliferation and differentiation and so on.Therefore,the module-based network analysis will be an effective method for better understanding TCM.

关键词(KeyWords): 三七皂苷;蛋白互作网络;功能模块;分子作用机制
Panax notoginseng saponins;protein interaction network;functional modules;molecular mechanisms

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划项目(2008BAI51B01);; 北京中医药大学自主课题项目(2013-JYBZZ-XS-072)

作者(Authors): 任真真;张燕玲;王星;王石峰;贺昱甦;翟晨曦;乔延江;
REN Zhen-zhen;ZHANG Yan-ling;WANG Xing;WANG Shi-feng;HE Yu-su;ZHAI Chen-xi;QIAO Yan-jiang;Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine;

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