中国中药杂志

2021, v.46(20) 5218-5225

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吴茱萸碱药理与毒理研究进展
Research progress in pharmacology and toxicology of evodiamine

杨春启;连闻雨;王宇光;高月;
YANG Chun-qi;LIAN Wen-yu;WANG Yu-guang;GAO Yue;Anhui Medical University;Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences;Guangdong Pharmaceutical University;

摘要(Abstract):

吴茱萸碱为芸香科植物吴茱萸,石虎和疏毛吴茱萸中的主要活性物质,是一种天然吲哚类生物碱。近年来由于其广泛的药理活性而逐渐被人们关注。目前研究发现吴茱萸碱能够显著抑制多种癌细胞增殖,诱导细胞周期阻滞以及细胞迁移等细胞进程。此外,吴茱萸碱在心血管类疾病(高脂血症等),手足癣等疾病中均具有显著药理活性。但目前研究发现吴茱萸碱具有潜在的毒性作用,如肝毒性,肾毒性以及心脏毒性等。然而吴茱萸碱的药理及毒理机制尚不明确,体内外毒性报道较少。因此该文对吴茱萸碱近年来的药理学和毒理学相关研究进行梳理和总结,为进一步深入研究吴茱萸碱提供研究思路及文献参考。
Evodiamine, a bioactive indole alkaloid from Evodia rutaecarpa, E. rutaecarpa var. officinalis, or E. rutaecarpa var. bodinieri, has been extensively investigated due to its pharmacological activities in recent years. At present, evodiamine is proved to significantly suppress the proliferation of a variety of cancer cells and mediate cell processes such as cell cycle arrest and cell migration. In addition, evodiamine displays significant pharmacological activities against cardiovascular diseases(hyperlipidemia, etc.), and tinea manus and pedis. Recently, evodiamine has been found to have potential toxic effects, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. However, the pharmacological and toxicological mechanism of evodiamine is not clear, and its toxicity in vitro and in vivo has been rarely reported. Therefore, this study reviewed the pharmacological and toxicological articles of evodiamine in recent years, aiming at providing new ideas and references for future research.

关键词(KeyWords): 吴茱萸碱;药理学;毒理学;TGF-β
evodiamine;pharmacology;toxicology;TGF-β

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2018YFC1704504)

作者(Author): 杨春启;连闻雨;王宇光;高月;
YANG Chun-qi;LIAN Wen-yu;WANG Yu-guang;GAO Yue;Anhui Medical University;Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences;Guangdong Pharmaceutical University;

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