中国中药杂志

2017, v.42(15) 2984-2988

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微型化介质研磨法制备槲皮素纳米混悬剂
Preparation of nanosuspension of quercetin with a miniaturized milling method

刘肖;刘娟;庞建云;申宝德;沈成英;连王权;李小芳;袁海龙;
LIU Xiao;LIU Juan;PANG Jian-yun;SHEN Bao-de;SHEN Cheng-ying;LIAN Wang-quan;LI Xiao-fang;YUAN Hai-long;College of Pharmacy,Chengdu University of Traditional Chinese Medicine;Department of pharmacy,Air Force General Hospital,PLA;

摘要(Abstract):

采用Box-Behnken设计-效应面法优化一种微型化介质研磨法制备槲皮素纳米混悬剂(QT-NS)的工艺参数并评价所制得的QT-NS的体外累积释放度。结果显示,以最优工艺参数:氧化锆珠子4.5 m L、研磨速度690 r·min-1、研磨时间1.5 h,制得的QT-NS的粒径为(169±5)nm,多分散度指数为0.204±0.006,稳定系数为0.827±0.014,且理论预测值与实测值偏差较小,模型具有良好的预测性;在120 min体外累积释放度实验中,QT-NS明显高于原料药和物理混合物。使用该种微型化介质研磨法能成功制备QT-NS,且该方法中原料药消耗少,工艺简单、操作方便,可为纳米制剂的制备提供新的参考。
The nanosuspension of quercetin( QT-NS) was prepared by a miniaturized milling method,and the process was optimized by Box-Behnken response surface method. Then the accumulative release rate of QT-NS in vitro was determined. The results showed that the optimal process parameters were as follows: Zr O24. 5 m L,milling speed 690 r·min-1and milling time 1. 5 h; the particle size of QT-NS was( 169 ± 5) nm,polydispersity index of 0. 204 ± 0. 006 and stability index of 0. 827 ± 0. 014,respectively.There was a little deviation between the theoretically predicted value and the measured value,indicating that this model had a good prediction effect. The accumulative release rate in vitro of QT-NS in 120 min was significantly higher than that of the raw drug and physical mixture. This simple low-cost miniaturization approach could prepare QT-NS successfully,and could provide reference for the formulation of the nanosuspension.

关键词(KeyWords): 槲皮素;纳米混悬剂;微型化介质研磨法;体外释放
quercetin;nanosuspension;miniaturized milling method;in vitro release

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81573697);; 后勤科研重点项目(BKJ16J011)

作者(Authors): 刘肖;刘娟;庞建云;申宝德;沈成英;连王权;李小芳;袁海龙;
LIU Xiao;LIU Juan;PANG Jian-yun;SHEN Bao-de;SHEN Cheng-ying;LIAN Wang-quan;LI Xiao-fang;YUAN Hai-long;College of Pharmacy,Chengdu University of Traditional Chinese Medicine;Department of pharmacy,Air Force General Hospital,PLA;

DOI: 10.19540/j.cnki.cjcmm.2017.0120

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