中国中药杂志

2020, v.45(21) 5110-5116

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脑缺血疾病相关离子通道研究进展及中药防治
Research progress of ion channels relating to cerebral ischemic diseases and prevention and treatment with traditional Chinese medicine

高家乐;刘建勋;
GAO Jia-le;LIU Jian-xun;Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences;

摘要(Abstract):

脑缺血(cerebral ischemia)是由于动脉粥样硬化或血栓形成造成脑内动脉狭窄或闭塞,引起脑组织缺血缺氧、神经元受损的一系列临床症状和体征,严重影响着人类的健康和生活质量。脑缺血累及"神经血管单元"系统的级联反应,最终影响了神经细胞的正常生理功能、发生系列病理学改变。在此过程中,细胞膜的各种离子通道结构和功能的变化起到了重要作用。该文从钾离子通道、钠离子通道、钙离子通道以及其他相关通道如AQP, TRPM2, TRPM7, TRPV4, ASICs, Cl~-通道等阐述了与脑缺血性疾病相关离子通道的变化,并从离子通道角度探讨了中药防治脑缺血性疾病的干预作用,以期为今后防治脑缺血性疾病的药物开发所涉及的潜在作用靶点提供一些参考。
Cerebral ischemia is a series of clinical symptoms and signs of cerebral ischemia, hypoxia and neuronal damage caused by cerebral artery stenosis or occlusion due to atherosclerosis or thrombosis, which seriously affects human health and quality of life. Cerebral ischemia involves the cascade reaction of the "neurovascular unit" system, and finally affects the normal physiological function of nerve cells and produces a series of pathological changes. And the changes in the structure and function of various ion channels in the cell membrane play an important role during this process. This article illustrates the changes in the ion channel associated with ce-rebral ischemic diseases, such as the potassium ion channels, sodium ion channels, calcium channels and other relevant channels, like AQP, TRPM2, TRPM7, TRPV4, ASICs, Cl~- channel, and explores the intervention effect of traditional Chinese medicine in prevention and treatment of cerebral ischemic diseases from the perspective of ion channels, in order to provide references for potential targets involving in drug development for the future prevention and treatment of cerebral ischemic diseases.

关键词(KeyWords): 离子通道;脑缺血;中药;研究进展
ion channels;cerebral ischemia;traditional Chinese medicine;research progress

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81873041)

作者(Author): 高家乐;刘建勋;
GAO Jia-le;LIU Jian-xun;Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200709.602

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