中国中药杂志

2014, v.39(14) 2665-2669

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不同产地加工方法对江苏省东海县种植基地金银花质量影响的研究
Influence of different processing methods on Lonicerae Japonicae Flos from Donghai cultivation base in Jiangsu province

王永香;罗勇;沈娟;周一飞;王振中;萧伟;
WANG Yong-xiang;LUO Yong;SHEN Juan;ZHOU Yi-fei;WANG Zheng-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

以绿原酸、木犀草苷含量,液相指纹图谱相似度为评价指标,考察自然晒干、烘房烘干、微波杀青烘干、滚筒杀青烘干、硫磺熏蒸阴干5种不同产地加工方法对江苏省东海县药材种植基地金银花质量的影响。结果表明不同产地加工方法对金银花药材中绿原酸含量、液相指纹图谱相似度有显著影响,对木犀草苷含量无明显差异。微波杀青烘干、滚筒杀青烘干样品绿原酸含量较高,分别为3.67%,3.39%,液相指纹图谱相似度分别为0.815,0.793;烘房烘干、硫磺熏蒸阴干样品绿原酸质量分数分别为2.87%,2.53%,液相指纹图谱相似度分别为0.964,0.765;晒干样品绿原酸质量分数最低为1.92%,液相指纹图谱相似度为0.940。根据研究结果,同时结合江苏康缘药业股份有限公司金银花药材内控标准,东海县种植基地金银花最佳加工方法为烘房烘干法,该研究为江苏省东海县药材基地金银花产地加工方法的确定提供了理论依据。
To study the impact of five different origin processing methods,namely natural drying,drying in baking shop,drying by microwave heating,drying in drum and drying with sulphur fumigation,on the quality of Lonicerae Japonicae Flos from Donghai cultivation base in Jiangsu Province,with the contents of chlorogenic acid and galuteolin and the similarity in HPLC fingerprints as the evaluation indicators. The results showed that different origin processing methods had significant impact on the content of chlorogenic acid and the similarity in HPLC fingerprints,but with no significant difference on the content of galuteolin. By means of drying by microwave heating and drying in drum,the samples showed higher contents of chlorogenic acid,respectively 3. 67% and 3. 39%. The similarities of HPLC fingerprints were 0. 815 and 0. 793,respectively. By means of the drying in baking shop and the drying with sulphur fumigation,the contents of chlorogenic acid in the samples were 2. 87% and 2. 53%,respectively. The similarities of HPLC fingerprints were 0. 964 and 0. 765,respectively. The lowest content of chlorogenic acid in naturally dried samples was 1. 92%. The similarity of HPLC fingerprints was 0. 940. According to the findings as well as the internal control standards for Lonicerae Japonicae Flos herbs of Jiangsu Kanion Pharmaceutical Co.,Ltd.,the optimum processing method for Lonicerae Japonicae Flos from Donghai cultivation base was the drying in baking shop. This study provided a theoretical basis for determining the processing method for Lonicerae Japonicae Flos from Donghai cultivation base of Jiangsu Province.

关键词(KeyWords): 江苏省东海县;金银花;产地加工方法;绿原酸;木犀草苷;液相指纹图谱相似度
Donghai county of Jiangsu province;Lonicerae Japonicae Flos;origin processing method;chlorogenic acid;mignonette;similarity of HPLC fingerprints

Abstract:

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 王永香;罗勇;沈娟;周一飞;王振中;萧伟;
WANG Yong-xiang;LUO Yong;SHEN Juan;ZHOU Yi-fei;WANG Zheng-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

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