中国中药杂志

2011, v.36(10) 1280-1285

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基于少腹逐瘀汤不同组合分析其理化参数与化学组成的变化特性
Analysis of morphic traits between physical and chemical properties and chemical constituents based on different combinations of Shaofu Zhuyu decoction

宿树兰;段金廒;朱华旭;尚尔鑫;华永庆;唐于平;
SU Shulan1,DUAN Jin′ao1,ZHU Huaxu1,SHANG Erxin1,HUA Yongqing1,TANG Yuping1(Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research,NanjingUniversity of Chinese Medicine,Nanjing 210046,China)

摘要(Abstract):

汤剂是传统中医主要的用药形式。该剂型具有制备简单、起效迅速等诸多特点。从现代科学认知水平看汤剂,其实质是一个复杂的物理化学体系。该文以少腹逐瘀汤经典方为研究对象,将该方药味采用逐药剔除与组对剔除的方法,制备成不同组合的若干组汤液,通过检测理化参数与分析化学组成,以考察和探讨其关联关系和变化特性;运用偏最小二乘回归方法对汤液理化参数与化学组成的相关性进行分析,以期为客观认识汤剂治疗疾病的物质状态、作用机制及其科学内涵提供参考。
The formulae decoctions are commonly used in clinic and have characteristics of simple preparation and rapid effect.It was considered as a complex physical and chemical system.In this article,the physical and chemical properties and chemical components and their relationships were investigated to explore the changes of characteristics resulted from different combinations of drugs of Shaofu Zhuyu decoction.The method of partial leasts-quares regression was adopted to evaluate the correlation between physical and chemical parameters and chemical components.These researches may provide a new way to investigate the state of bioactive components,the action mechanisms,and property of treating diseases of traditional Chinese medicine decoction.

关键词(KeyWords): 少腹逐瘀汤;理化参数;化学组成;变化特性
Shaofu Zhuyu decoction;physical and chemical parameters;chemical components;morphictraits

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基金项目(Foundation): 国家自然科学基金项目(30973885);; 江苏省高校自然基金重大基础研究项目(06KJA36022);; 江苏省中医药管理局项目(LB09016);; 南京中医药大学青年自然科学基金项目(09XZR15)

作者(Author): 宿树兰;段金廒;朱华旭;尚尔鑫;华永庆;唐于平;
SU Shulan1,DUAN Jin′ao1,ZHU Huaxu1,SHANG Erxin1,HUA Yongqing1,TANG Yuping1(Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research,NanjingUniversity of Chinese Medicine,Nanjing 210046,China)

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