中国中药杂志

2005, (02)

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鸡血藤有效成分研究
Studies on the active constituents in vine stem of Spatholobus suberectus

崔艳君,刘屏,陈若芸
CUI Yan-jun~1, LIU Ping~2, CHEN Ruo-yun~1(1.Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 China; 2.The General Hospital of Chinese People Liberation Army, Beijing 100853, China)

摘要(Abstract):

目的 :研究鸡血藤原植物密花豆Spatholobussuberectus的有效成分。方法 :利用各种色谱技术进行分离纯化 ,根据理化性质和各种波谱技术进行结构鉴定。结果 :分离鉴定了 8个化合物 ,分别为芒柄花苷 (ononin ,1) ,樱黄素 (prunetin ,2 ) ,没食子儿茶素 (gallocatechin ,3) ,儿茶素 (catechin ,4 ) ,表儿茶素 (epicatechin ,5 ) ,丁香酸 (syringicacid ,6 ) ,香草酸 (vanillicacid ,7) ,胡萝卜苷 (daucosterol,8)。结论 :化合物 3,4 ,6 ,7为首次从密花豆属中分离得到。其中化合物 4对骨髓抑制小鼠造血祖细胞的增殖有刺激活性
Objective: To study the active constituents in vine stem of Spatholobus suberectus. Method: The constituents of Spatholobus suberectus were systematically separated with various chromatographic techniques. The structures were elucidated by physico-chemical properties and spectral data. Result: Eight compounds were isolated from S. suberectus, and were identified as: ononin (1), pruneitin (2), gallocatechin (3), catechin (4), epicatechin (5), syringic acid(6), vanillic acid(7) and daucosterol(8). Conclusion: Compound 3,4,6,7 were obtained from Spatholobus genus for the first time. Compound 4 has stimulation to proliferation of hematopoietic progenitor cell.

关键词(KeyWords): 鸡血藤;密花豆;没食子儿茶素;儿茶素;表儿茶素
Caulis Spatholobi; Spatholobus suberectus; gallocatechin; catechin; epicatechin

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基金项目(Foundation): 国家自然科学基金资助项目 (3 0 0 70 890 )

作者(Author): 崔艳君,刘屏,陈若芸
CUI Yan-jun~1, LIU Ping~2, CHEN Ruo-yun~1(1.Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 China; 2.The General Hospital of Chinese People Liberation Army, Beijing 100853, China)

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