中国中药杂志

2013, v.38(12) 1942-1946

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柔毛淫羊藿叶黄酮类成分研究
Flavonoids from leaves of Epimedium pubescens

张红飞;闫利华;张启伟;王智民;
ZHANG Hong-fei1,2,3,YAN Li-hua1,3*,ZHANG Qi-wei1,3,WANG Zhi-min1,3*(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China; 3.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine,Beijng 100700,China)

摘要(Abstract):

对柔毛淫羊藿Epimedium pubescens叶的化学成分进行研究。采用硅胶,Sephadex LH-20,MCI柱色谱及制备、半制备HPLC等方法进行分离和纯化,根据理化性质和波谱数据鉴定化合物结构。从柔毛淫羊藿叶的70%乙醇提取物中分离得到11个化合物,分别鉴定为脱水淫羊藿素(1),淫羊藿次苷Ⅱ(2),2'''-O-鼠李糖基淫羊藿次苷Ⅱ(3),去甲基脱水淫羊藿素(4),宝藿苷Ⅱ(5),朝霍素B(6),粗毛淫羊藿苷(7),苜蓿素(8),山柰酚(9),大豆素(10),对羟基苯甲酸乙酯(11)。其中化合物11为首次从淫羊藿属植物中分离得到,其余10个化合物为首次从该植物中分离得到。
Eleven compounds were isolated from the leaves of Epimedium pubescens by means of various chromatographic techniques such as silica gel,MCI,Sephadex LH-20 and preparative HPLC.Their structures were identified as anhydroicaritin(1),icarisideⅡ(2),2'''-O-rhamonosyl-icarisideⅡ(3),desmethylanhydroicaritin(4),baohuosaideⅡ(5),epimedokoreanin B(6),acuminatin(7),tricin(8),kaempferol(9),daidzein(10) and 4-hydroxy ethyl benzoate(11) on the basis of physicochemical properties and spectroscopic data analysis.Among them,compound 11 was isolated from Epimedium species for the first time,and other compounds were obtained from this plant for the first time.

关键词(KeyWords): 柔毛淫羊藿;化学成分;异戊烯基黄酮
Epimedium pubescens;chemical constituents;prenyl flavonoids

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2009ZX09308-003,2009ZX09301-005);; 中国中医科学院自主选题项目(2011xycz-11)

作者(Authors): 张红飞;闫利华;张启伟;王智民;
ZHANG Hong-fei1,2,3,YAN Li-hua1,3*,ZHANG Qi-wei1,3,WANG Zhi-min1,3*(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China; 3.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine,Beijng 100700,China)

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