中国中药杂志

2021, v.46(17) 4323-4333

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紫檀素化合物及其生物活性研究的新进展
Pterocarpans and their biological activities: a review

黄新苹;
HUANG Xin-ping;Zhengzhou Normal University;

摘要(Abstract):

紫檀素类化合物(pterocarpans)是由植物的化学防御系统产生的具有自我保护的活性物质,广泛存在于豆科蝶形花亚科植物,2006年之前从自然界共发现144个紫檀素类化合物。该文首次报道的近15年新发现的89个紫檀素化合物不仅具有立体多样性、新颖性、复杂性、种属性等结构特征,而且具有很好的抗菌、抗肿瘤、抗氧化、杀虫、抗炎等生物活性;对其生物代谢途径的推测和药理活性的研究,进一步证实了构效相关性;富含紫檀素的豆科植物分布具有很强的地域性特征,加强对中国分布的豆科植物资源的研究和利用,提高具有地理标志性的植物资源的知名度和推广应用价值。该文为进一步研究、开发和利用紫檀素化合物及其来源植物提供有效参考。
Pterocarpans, ubiquitous in Fabaceae, are protective active substances produced by the chemical defense system of plants. A total of 144 pterocarpans had been discovered before 2006. For the first time, we reported the 89 pterocarpans identified in 2006—2020. These pterocarpans not only demonstrate novel complex diversified genus-specific stereostructures but also display strong anti-microbial, anti-tumor, antioxidant, insecticidal, and anti-inflammatory activities. Through the projection of their biogenetic pathways and study of the pharmacological activities, the structure-activity correlation was further confirmed. The distribution of Leguminosae plants rich in pterocarpans has obvious regional characteristics. Therefore, the research and utilization of Leguminosae plant resources in China should be strengthened, and the popularity and application value of the geographical indicator plant resources should be improved. This paper serves as a reference for further research, development, and utilization of pterocarpans and their plant sources.

关键词(KeyWords): 紫檀素;豆科植物;生物活性
pterocarpan;Leguminosae plant;biological activity

Abstract:

Keywords:

基金项目(Foundation): 河南省科技攻关重点项目(182102310615)

作者(Authors): 黄新苹;
HUANG Xin-ping;Zhengzhou Normal University;

DOI: 10.19540/j.cnki.cjcmm.20210528.602

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