中国中药杂志

2014, v.39(13) 2417-2421

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基于温辛肝功效网络的活血化淤治法抗肝癌作用机制解析
Analysis on anti-hepatoma effect of medicine invigorating blood circulation and eliminating blood stasis based on warm-pungent-liver efficiency network

顾浩;马莉;袁斌;张燕玲;王耘;乔延江;
GU Hao;MA Li;YUAN Bin;ZHANG Yan-ling;WANG Yun;QIAO Yan-jiang;Information Engineering Research Center for Traditional Chinese Medicines,Beijing University of Chinese Medicine;

摘要(Abstract):

目的:功效网络是揭示中药功效作用机制和功效间关系的复杂网络。利用功效-药性的关系,构建温辛肝活血功效网络,阐明活血治疗肝癌的原理。以温辛归肝经的活血药红花为例,探讨功效网络在中药有效成分辨识及组合配伍中的应用。方法:该文利用前期工作中,活血功效的相关药性组合温辛肝为研究对象,收集具有温辛肝药性中药的药理作用数据,利用关联规则方法和卡方检验得到温辛肝活血关联度最高的药理作用组合。利用DrugBank数据库收录的药理靶点数据,在蛋白质相互作用网络背景下,根据"功效-药性-药理-靶点-蛋白相互作用"为主线,构建温辛肝活血功效网络。结果:活血一方面通过影响原癌基因、抑癌基因、细胞凋亡、抗炎直接治疗肝癌,另一方面可以通过抗凝、抗黏、调节局部血循环,防止癌细胞转移和增强组织对抗癌药敏感性,从而间接治疗肝癌。基于活血网络靶点筛选的红花有效成分群中,红花黄色素、槲皮素和木犀草素等已有文献证明具有抗肝癌作用,说明了该文结果的可靠性以及功效网络的用途。结论:功效网络是揭示中药治法作用机制的有效途径,并能够在此基础上发现中药治疗特定疾病的关键有效成分。
Objective: The efficiency network is a complicated network for revealing the efficient mechanism of traditional Chinese medicines(TCMs) and relations among efficiencies. The efficiency-property relations were used to establish a warm-pungent-liver efficiency network to explain the principle of treating hepatoma with medicines invigorating blood circulation and eliminating blood stasis. Safflower,a warm-pungent medicine distributing along the live meridian,was taken for example to discuss the efficiency network's application in the identification of active ingredients of TCMs and the combination. Method: In the early stage of this study,combined warm-pungent-liver medicines distributed along the liver meridian and invigorating blood circulation and eliminating blood stasis were taken as the study objects to collect the pharmacological effect data of warm-pungent-liver medicines and obtain the pharmacological effect combinations with the highest blood circulation-invigorating association by the association rules and the chi-square test. The pharmacological target data recorded in the DrugBank database is used to establish the warm-pungent-liver efficiency network according to the principle line of ″efficiency-property-pharmacology-target-protein interaction″ under the background of the protein interaction network. Result: The blood circulation-invigorating medicines could directly treat hepatoma by impacting protooncogene,cancer suppressor gene,cell apoptosis and anti-inflammation,and indirectly treat hepatoma by resisting coagulation and adhesion,regulating local blood circulation,preventing cancer cell metastasis and enhancing the tissues' sensitivity to the anticancer drugs. Among the active ingredients of safflower screened based on the blood circulation-invigorating network targets,carthamin yellow,quercetin and luteolin have been proved to have the anti-hepatoma effect in literatures,which indicated the reliability of this study's results and the purpose of the efficiency network. Conclusion: The efficiency network is an effective method for revealing the TCM' s mechanism,and lays a foundation for discovering key active ingredients of TCMs for treating specific diseases.

关键词(KeyWords): 活血;功效网络;肝癌
invigorate blood circulation;efficiency network;hepatoma

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81373985,81173568);; 教育部新世纪优秀人才支持项目(NECT-11-0605);; 国家科技支撑计划项目(2008BAI51B01);; 北京中医药大学科研创新团队支持项目(2011-CXTD-11);; 北京中医药大学校级课题(2013-JYBZZ-XS-110)

作者(Author): 顾浩;马莉;袁斌;张燕玲;王耘;乔延江;
GU Hao;MA Li;YUAN Bin;ZHANG Yan-ling;WANG Yun;QIAO Yan-jiang;Information Engineering Research Center for Traditional Chinese Medicines,Beijing University of Chinese Medicine;

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