中国中药杂志

2009, v.34(09) 1086-1089

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不同炮制时间附子饮片双酯型生物碱含量变化与饮片安全的相关性研究
Changes of DDAs content affected by different processing time and it relationship with safety of processed Fuzi

李志勇;张硕峰;畅洪昇;孙建宁;李飞;
LI Zhiyong1,2,ZHANG Shuofeng1,CHANG Hongsheng1,SUN Jianning1,LI Fei1(1.School of Chinese Pharmacy of Beijing University of Chinese Medicine,Beijing 100102,China;2.China Minority Traditonal Medical Center of Minzu University of China,Beijing 100081,China)

摘要(Abstract):

目的:对不同炮制时间附子饮片的毒-效性与饮片3种双酯型生物碱的含量变化进行相关性研究。方法:以附子"回阳救逆"功效为评价重点,采用Bliss法和序贯法对不同炮制时间附子饮片进行安全性评价;将饮片乌头碱、中乌头碱、次乌头碱含量变化与饮片TD50,ED50,TI进行关联性分析,并对3种双酯型生物碱与饮片毒性、药效的相关性进行分析。结果:具有"回阳救逆"功效和"高效低毒"特点的附子饮片保存了适量的中乌头碱和次乌头碱,乌头碱干扰了附子"回阳救逆"功效的显现(负相关),次乌头碱与附子的毒性和"回阳救逆"功效均成正相关。结论:中乌头碱、次乌头碱在饮片中的适当配比存在是保证附子"回阳救逆"及安全性的关键。
Objective: To study the correlation between content changes of Diester diterpenoid alkaloids(DDAs) content and safety of the processed Fuzi.Method: Sequential and Bliss methods were used to evaluate the safety of 7 kinds of Fuzi processed with different processing time.The relationship between ED50,TD50,TI and content changes of DDAs of those processed Fuzi was studied,the correlation between the content changes and effect of different processed Fuzi was analyzed,and the toxicity of those processed Fuzi with multiple linear regression was tested.Result: Fuzi with good efficiency and safety contains proper hypaconitine(HA) and mesaconitine(MA).Aconitine(AC) interfered efficacy of Fuzi(negative correlation),HA showed positive correlation with toxicity and efficacy of Fuzi.Conclusion: HA and MA kept in determinate proportion are very important for the safety and effectivity of processed Fuzi.

关键词(KeyWords): 附子;炮制;相关性
Fuzi;process;correlation

Abstract:

Keywords:

基金项目(Foundation): 国家“十五”科技攻关计划重大项目(2004BA721A11)

作者(Author): 李志勇;张硕峰;畅洪昇;孙建宁;李飞;
LI Zhiyong1,2,ZHANG Shuofeng1,CHANG Hongsheng1,SUN Jianning1,LI Fei1(1.School of Chinese Pharmacy of Beijing University of Chinese Medicine,Beijing 100102,China;2.China Minority Traditonal Medical Center of Minzu University of China,Beijing 100081,China)

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