中国中药杂志

2019, v.44(07) 1485-1490

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祛湿类单味中药对尿酸代谢的研究
Effect of single-herb traditional Chinese medicine for eliminating dampness on metabolism of uric acid

褚梦真;张冰;林志健;张晓朦;王雨;
CHU Meng-zhen;ZHANG Bing;LIN Zhi-jian;ZHANG Xiao-meng;WANG Yu;School of Chinese Pharmacy, Beijing University of Chinese Medicine;

摘要(Abstract):

通过查阅文献对具有降尿酸作用的单味中药进行研究发现,对比其他类单味中药,祛湿类单味中药降尿酸的文献报道居多,那么祛湿类单味中药与尿酸之间有何联系?是如何发挥降尿酸作用?该研究以2015年版《中国药典》、新世纪全国高等中医院校创新教材《临床中药学》中祛湿类中药为研究对象,通过中国知网(CNKI)、万方、维普等对祛湿类单味中药治疗高尿酸血症的文章进行检索。后采用Excel(2016)建立数据库,应用Excel筛选工具提取其降尿酸作用、药效部位、降尿酸途径及作用机制等分类统计,以明确祛湿类单味中药与尿酸之间的联系及其降尿酸的作用机制。整理结果显示:祛湿类的67味单味中药中,有降尿酸作用的中药共有16种,占所研究中药的23.88%;其他发挥降尿酸作用的有中药提取物和化学成分等;其降尿酸的途径主要为:抑制尿酸合成和促进尿酸排泄;作用机制多为调节尿酸生成的2个关键酶及尿酸排泄的离子转运蛋白。由此可见此类中药降尿酸作用明确,为治疗高尿酸血症的药物筛选、组方配伍和靶点确定,提供了新思路,为高尿酸血症的临床治疗和研究提供了理论依据。
Through literature review, it was found that there were many literature reports on the effect of single-herb traditional Chinese medicine for lowering uric acid in comparison with other single-herb traditional Chinese medicines. Then what is the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid? How do they play a role in lowering uric acid? In this study, traditional Chinese medicines for eliminating dampness in the 2015 Chinese Pharmacopoeia and the innovative textbook of Clinical Chinese Pharmacy for Chinese medicine colleges and universities in the new century were selected as the research objects, and articles about the effect of single-herb traditional Chinese medicines for eliminating dampness in the treatment of hyperuricemia were searched through CNKI, WanFang and VIP. Afterwards, Excel(2016) was used to establish a database, and Excel screening tool was used to extract the classification statistics of its uric acid lowering effect, pharmacodynamic sites, uric acid lowering pathway and mechanism, so as to clarify the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid as well as their mechanism on lowering uric acid. The results showed that there were 16 kinds of traditional Chinese medicines with uric acid lowering effect, accounting for 23.88% of the 67 kinds of traditional Chinese medicines for eliminating dampness. Other medicines with the uric acid lowering effect included traditional Chinese medicine extracts and chemical components. The main ways of reducing uric acid included: inhibiting uric acid synthesis and promoting uric acid excretion; mechanism of action was mainly regulating the two key enzymes generated by uric acid and the ion transporters excreted by uric acid. Therefore, it can be seen that this kind of traditional Chinese medicines have a clear effect in reducing uric acid, providing new ideas for drug screening, prescription compatibility and target determination for the treatment of hyperuricemia as well as a theoretical basis for the clinical treatment and research of hyperuricemia.

关键词(KeyWords): 祛湿类中药;湿邪;尿酸
traditional Chinese medicine for eliminating dampness;damp evil;uric acid

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2017ZX09301024);; 国家自然科学基金项目(81673618)

作者(Author): 褚梦真;张冰;林志健;张晓朦;王雨;
CHU Meng-zhen;ZHANG Bing;LIN Zhi-jian;ZHANG Xiao-meng;WANG Yu;School of Chinese Pharmacy, Beijing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20181213.004

参考文献(References):

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