中国中药杂志

2009, v.34(01) 47-49

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冬凌草甲素水溶液稳定性研究
Study on stability of oridonin solution

许洁;赵继会;王菊;冯年平;谭蓉;刘颖;
XU Jie,ZHAO Jihui,WANG Ju,FENG Nianping,TAN Rong,LIU Ying (Department of Pharmaceutics,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

摘要(Abstract):

目的:考察冬凌草甲素(ORI)水溶液的稳定性,为ORI新型给药系统的研究奠定基础。方法:在室温下将ORI水溶液分别用1mol·L-1的NaOH或HCl调节pH至设定值,放置60h,考察pH对ORI水溶液稳定性的影响;采用经典恒温法预测ORI水溶液在室温下和4℃条件下的稳定性。结果:ORI降解的pH-速率曲线呈V型,最稳定的pH(pHm)为5。ORI的水溶液在室温下有效期(t90)为53.2h,4℃下为91.5h。结论:ORI水溶液不稳定,其降解反应速度受溶液pH的影响,属于酸碱专属催化反应。
Objective:To investigate the stability of oridonin(ORI) solution for research and development of novel ORI prepartions. Method:The effect of pH on the degradation rate of ORI was evaluated,the pH values of the oridonin solutions were adjusted to the setting pH,with 1 mol·L-1 HCl or NaOH,respectively,and stored at room temperature for 60 h. The constant temperature method was applied to evaluate the stability of ORI solution at room temperature and at 4 ℃. Result:The pH-rate profile of ORI was V-shaped,and the pHm was 5. The t90 of ORI solution at room temperature was 53.2 h and 91.5 h at 4 ℃ Conclusion:The ORI solution is not stable. The pH-dependent degradation of ORI solution confirms to specific acid-base catalysis reaction.

关键词(KeyWords): 冬凌草甲素;稳定性;pH;恒温
oridonin;stability;pH;constant temperature method

Abstract:

Keywords:

基金项目(Foundation): 上海市博士点基金(2006B02);; 上海市教委重点学科项目(J50302);; 上海市科委(0852nm05300)

作者(Authors): 许洁;赵继会;王菊;冯年平;谭蓉;刘颖;
XU Jie,ZHAO Jihui,WANG Ju,FENG Nianping,TAN Rong,LIU Ying (Department of Pharmaceutics,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

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