中国中药杂志

2008, (16) 2019-2022

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黄芩脂质过氧化抑制率与有效成分含量的相关性研究
Relationship between antioxidant activities and contents of active ingredients in Radix Scutellaria

杨滨;梁日欣;周晓宁;高伟;黄璐琦;
YANG Bin,LIANG Ri-xin,ZHOU Xiao-ning,GAO Wei,HUANG Lu-qi(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

摘要(Abstract):

目的:对黄芩脂质过氧化抑制率与有效成分含量的相关性进行研究。方法:建立鼠肝微粒体脂质过氧化模型,以硫代巴比妥酸法评估黄芩及其主要成分黄芩素、黄芩苷和汉黄芩素不同比例组合样品在此模型中的抗脂质过氧化活性。结果:抗脂质过氧化活性以黄芩素最强,依次为黄芩苷和汉黄芩素。黄芩药材的IC50在2.72~18.27 mg.L-1。结论;黄芩的抗脂质过氧化活性除与有效成分的浓度有关外,还与其组成的比例密切相关。
Objective: To study the relationship between the antioxidant activities and the contents of active ingredients in Radix Scutellaria.Method: The antioxidant activities of extracts and active ingredients of Radix Scutellaria in NADPH-dependent lipid peroxidation in rat liver microsome were assayed.Result: Extracts of Radix Scutellaria showed a 50% inhibition of lipid peroxidation in the concentration range of 2.72-18.27 mg·L-1.Conclusion: The antioxidant activities of extracts of Radix Scutellaria are not only related with the contents but also the ratio of the active ingredients.

关键词(KeyWords): 黄芩;脂质过氧化抑制率;有效成分含量;相关性
Radix Scutellaria;inhibition of lipid peroxidation;contents of active ingredients;relationship

Abstract:

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基金项目(Foundation): 北京市科技新星计划项目(H020821410190);; 国际科技合作项目(2006DFB31720)

作者(Author): 杨滨;梁日欣;周晓宁;高伟;黄璐琦;
YANG Bin,LIANG Ri-xin,ZHOU Xiao-ning,GAO Wei,HUANG Lu-qi(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

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