中国中药杂志

2020, v.45(03) 531-538

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补阴中药治疗糖尿病及其并发症物质基础及机制研究新思路
New thoughts on material basis and mechanism of Yin-tonifying traditional Chinese medicine in treatment of diabetes mellitus and its complications

袁海建;林淑媛;张光际;金建明;贾晓斌;陈靖靖;封亮;
YUAN Hai-jian;LIN Shu-yuan;ZHANG Guang-ji;JIN Jian-ming;JIA Xiao-bin;CHEN Jing-jing;FENG Liang;Taizhou Polytechnic College;School of Traditional Chinese Pharmacy, China Pharmaceutical University;

摘要(Abstract):

糖尿病在临床较为常见,患者血糖偏高,常伴有并发症,是一种严重慢性代谢性疾病。在医药界,中医对糖尿病的认识和研究最早。中医研究认为,糖尿病的临床特点与"消渴"基本一致,同时也认为"阴虚燥热"是消渴病的主要病机。基于上述认识,补阴中药被中医临床广泛用于治疗消渴病或糖尿病。目前用于糖尿病治疗的常见补阴中药有石斛、百合、麦冬、黄精等,上述药材中治疗糖尿病的有效成/组分以多糖类物质多见,可以治疗糖尿病的并发症包括血管病变、肾病变、视网膜病变、周围神经病变等。但从文献报道来看,除个别补阴中药防治糖尿病的有效成分相对明确外,大部分补阴中药治疗糖尿病还停留在水、醇等提取物或多糖等粗糙混合物层面。由于降糖药效物质基础、量效关系、机制靶点等尚不完全清楚,使补阴中药在临床应用中受到一定限制,也使其深入研究面临一定困难。该文通过对补阴中药治疗糖尿病及其并发症相关文献资料进行归纳,分析存在问题,提出基于色谱技术和代谢组学为主的研究思路与方法,以期为补阴中药的应用开发提供参考。
Diabetes mellitus is a serious chronic metabolic disease, and the patient′s hyperglycemia is often accompanied by complications. In the circles of medical science, traditional Chinese medicine(TCM) has the earliest knowledge and research about diabetes. According to TCM, the clinical characteristics of diabetes mellitus were basically the same as "Xiaoke". TCM also believes that "Yin deficiency and dryness heat" was the main pathogenesis of diabetes. Therefore, Yin-tonifying TCMs is widely used in clinical treatment of diabetes mellitus, including Dendrobii Caulis, Lilii Bulbus, Ophiopogonis Radix, Polygonati Rhizome. The effective component for treating diabetes in the above Chinese materia medica is polysaccharides, which is used to treat complications of diabetes mellitus, like vascular disease, nephropathy, retinopathy, peripheral neuropathy. According to literature reports, except for specific some Yin-tonifying TCMs with effective ingredients for preventing and treating diabetes, other Yin-tonifying TCMs only contain water, alcohol extracts or polysaccharides in the treatment of diabetes. However, due to unclear material basis, dose-effect relationship and mechanism target of hypoglycemic drugs, Yin-tonifying TCMs are restricted in clinical application, with certain difficulties in in-depth studies. In this paper, the literatures related to the treatment of diabetes mellitus and its complications with Yin-tonifying TCM are analyzed and summarized, the existing problems are analyzed, and the research ideas and methods based on chromatographic technology and metabonomics are put forward, in order to provide reference for the application and development of Yin-tonifying TCM.

关键词(KeyWords): 补阴中药;糖尿病;物质基础
Yin-tonifying traditional Chinese medicine;diabetes mellitus;material basis

Abstract:

Keywords:

基金项目(Foundation): 江苏省高等学校自然科学研究项目(18KJB360014);; 泰州市科技支撑计划项目(TS201721);; 泰州职业技术学院科研项目(TZYKY-17-25);泰州职业技术学院博硕基金项目(TZYBS-17-7);泰州职业技术学院创新型科研团队项目(TZYTD-16-1);; 江苏省“青蓝工程”项目(2016);; 江苏省大学生创新计划项目(201812106001Y,201812106002Y,201812106003Y)

作者(Author): 袁海建;林淑媛;张光际;金建明;贾晓斌;陈靖靖;封亮;
YUAN Hai-jian;LIN Shu-yuan;ZHANG Guang-ji;JIN Jian-ming;JIA Xiao-bin;CHEN Jing-jing;FENG Liang;Taizhou Polytechnic College;School of Traditional Chinese Pharmacy, China Pharmaceutical University;

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DOI: 10.19540/j.cnki.cjcmm.20190826.502

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