中国中药杂志

2014, v.39(04) 618-622

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基于数据挖掘的国医大师颜正华含陈皮处方用药规律研究
Analysis on medication rules of state medical master Yan Zhenghua from prescriptions with Citri Reticulatae Pericarpium based on data mining

吴嘉瑞;郭位先;张冰;张晓朦;杨冰;盛晓光;
WU Jia-rui;GUO Wei-xian;ZHANG Bing;ZHANG Xiao-meng;YANG Bing;SHENG Xiao-guang;Beijing University of Chinese Medicine;

摘要(Abstract):

该研究在收集处方的基础上,基于中医传承辅助系统构建数据库,进而应用关联规则apriori算法等数据挖掘方法,分析常用单味药物频次、药物组合频次、关联规则与核心药物组合等。研究显示,含陈皮处方常用于治疗胃痛、咳嗽等病证,高频次药物组合包括"陈皮-茯苓"、"赤芍-陈皮"等,置信度为1的关联规则包括"甘草→陈皮"、"白芍-香附→陈皮"、"茯苓→陈皮"等,处方所用药物多具理气活血等功效,用药较为集中,组方法度清晰。
The prescriptions containing pericarpium citri reticulatae that built by Professor.Yan were collected to build a database based on traditional Chinese medicine(TCM) inheritance assist system.After analyzed by data mining,such as apriori algorithm,the frequency of single medicine,the frequency of drug combination,the association rules between drugs and core drug combinations can be get from the database.Through the analysis of 1 027 prescriptions with pericarpium citri reticulatae,these prescriptions were commonly used to treat stomach aches,cough and other syndromes.The most frequency drug combinations were " Citri Reticulatae Pericarpium-Poria", " Paeoniae Radix Rubra-Citri Reticulatae Pericarpium" and so on.The drug association rules that the confidence was 1 were " Glycyrrhizae Radix ex Rhizoma→Citri Reticulatae Pericarpium", " Paeoniae Alba Radix-Cyperi Rhizoma→Citri Reticulatae Pericarpium", " Poria→Citri Reticulatae Pericarpium",and so on.The drugs in the prescriptions containing pericarpium citri reticulatae that built by Professor Yan mostly had the effects of regulating the flow of Qi and invigorate blood circulation,which reflected the clearly thought when making prescriptions.

关键词(KeyWords): 陈皮;数据挖掘;关联规则
Citri Reticulatae Pericarpium;data mining;association rules

Abstract:

Keywords:

基金项目(Foundation): 北京市自然科学基金项目(7112075);; 北京市中医药科技发展基金项目(JJ-2010-70);; 北京中医药大学科研创新团队项目(2011-CXTD-14);; 国家科技支撑计划项目(2007BAI10B01);; 北京中医药大学“重点学科”开放课题(2013-ZDXKKF-19)

作者(Author): 吴嘉瑞;郭位先;张冰;张晓朦;杨冰;盛晓光;
WU Jia-rui;GUO Wei-xian;ZHANG Bing;ZHANG Xiao-meng;YANG Bing;SHENG Xiao-guang;Beijing University of Chinese Medicine;

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