中国中药杂志

2021, v.46(04) 767-771

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基于中西医临床病症特点的分泌性中耳炎动物模型分析
Animal model analysis of secretory otitis media based on characteristics of clinical symptoms of traditional Chinese and Western medicine

张亚楠;白明;惠香香;王赛;苗明三;
ZHANG Ya-nan;BAI Ming;HUI Xiang-xiang;WANG Sai;MIAO Ming-san;College of Pharmacy,Henan University of Chinese Medicine;

摘要(Abstract):

基于分泌性中耳炎的中西医临床病症特点,参考临床诊断标准,整理分析并建立分泌性中耳炎的西医诊断标准和中医辨证标准,总结分泌性中耳炎动物模型的造模方法和模型特点,依据临床诊断标准及症状特点,对现有的动物模型与临床症状的吻合程度进行评价,明确其优缺点。统计结果发现,目前分泌性中耳炎动物模型的造模方法较少,且仅能揭示出某一种相关致病机制,其中吻合度较高的模型是基因工程技术造模和向中耳耳泡注入细菌因子2种造模方法,与西医临床病症吻合度较高,但均未能体现中医证型。因此建立同时体现分泌性中耳炎中西医临床病症特点的动物模型,完善分泌性中耳炎病症结合动物模型评价标准,是分泌性中耳炎中医药未来研究的主要任务。
Based on the characteristics of clinical symptoms of secretory otitis media in traditional Chinese and Western medicine,by reference to clinical diagnostic criteria,efforts were made to analyze and establish the Western medical diagnostic criteria and traditional Chinese medicine( TCM) syndrome differentiation criteria for secretory otitis media,and summarize the modeling methods and model characteristics of secretory otitis media animal models. According to the clinical diagnostic criteria and symptom characteristics,the coincidence degree between the existing animal models and clinical symptoms was evaluated,and its advantages and disadvantages were defined. On the basis of the statistical results,there were fewer methods for modeling secretory otitis media animal models,and only a specific relevant pathogenic mechanism could be revealed. Among them,the model with a higher coincidence degree was genetic engineering technology modeling and injection into the middle ear vesicles. The two modeling methods of bacterial factors highly coincided with the clinical symptoms of Western medicine,but both failed to reflect the TCM syndrome type. Therefore,establishing an animal model that simultaneously reflects the characteristics of clinical symptoms of secretory otitis media in traditional Chinese and Western medicine,and improving the evaluation criteria of secretory otitis media based on animal models are the main tasks of future studies on secretory otitis media.

关键词(KeyWords): 分泌性中耳炎;临床病症;动物模型
secretory otitis media;clinical symptoms;animal model

Abstract:

Keywords:

基金项目(Foundation): 国家国际合作基地项目(2016-65);; 中原学者项目(162101510003);; 河南省杰出外籍科学家工作室项目(GZS2019006);; 国家中医药管理局中医药标准化专项(2017-149-11)

作者(Author): 张亚楠;白明;惠香香;王赛;苗明三;
ZHANG Ya-nan;BAI Ming;HUI Xiang-xiang;WANG Sai;MIAO Ming-san;College of Pharmacy,Henan University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20201113.601

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