中国中药杂志

2015, v.40(13) 2679-2683

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表观遗传与药材道地性研究探讨
Relationship of epigenetic and Dao-di herbs

袁媛;魏渊;于军;黄璐琦;
YUAN Yuan;WEI Yuan;YU Jun;HUANG Lu-qi;State Key Laboratory of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;College of pharmacy,Jiangsu university;Key Laboratory of Genome Science and Information,China Academy of Science;

摘要(Abstract):

道地药材具有特异性、地域性特点,其独特的表型特征与药用植物的生长发育有着密切的关系。除经典遗传之外,表观遗传现象在药材道地性形成中发挥重要作用。该文介绍了表观遗传的范畴以及DNA甲基化在基因表达调控中的作用,并从道地药材特异性表型、地域性形成特征入手,展望表观遗传在药材道地性形成机制研究中的前景,为道地药材质量评价和鉴别提供依据。
Dao-di Herbs is specificity and locality,and its unique phenotypic features is closely related to the growth and development of medicinal plants. In addition to traditional genetic,epigenetic play an important role in formation of Dao-di herbs. This paper introduces the concept of epigenetic and the role of DNA methylation in the gene expression regulation. We further prospects epigenetic mechanism in study of Dao-di herbs formation from specific phenotype and regional analysis. And study on the relationship of epigenetic and Dao-di herbs will provide a basis for quality assessment and identification of Chinese drugs.

关键词(KeyWords): 道地药材;表观遗传;表型特征;环境胁迫
Dao-di herbs;epigenetic;phenotype;environmental stress

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基金项目(Foundation): 国家自然科学基金项目(81373959);; 国家高技术研究发展计划(863)项目(SS2014AA022201);; 科技基础性工作专项(2015FY111500);; 中医药行业科研专项(201407003)

作者(Author): 袁媛;魏渊;于军;黄璐琦;
YUAN Yuan;WEI Yuan;YU Jun;HUANG Lu-qi;State Key Laboratory of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;College of pharmacy,Jiangsu university;Key Laboratory of Genome Science and Information,China Academy of Science;

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