刘珊珊;郭杰;李宗艾;田双双;朱晶晶;闫利华;王智民;高陆;
LIU Shan-shan;GUO Jie;LI Zong-ai;TIAN Shuang-shuang;ZHU Jing-jing;YAN Li-hua;WANG Zhi-min;GAO Lu;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences;Tianjin University of Traditional Chinese Medicine;Xiuzheng Pharmaceutical Group Co., Ltd.;

• 1:中国中医科学院中药研究所中药质量控制技术国家工程实验室
• 2:天津中医药大学
• 3:修正药业集团股份有限公司

摘要(Abstract)：

泽泻为我国传统中药,广泛应用于中医临床复方及多种中成药中。目前从泽泻中分离到了220余个化合物,包括三萜、倍半萜、二萜、糖类、含氮化合物、苯丙素、黄酮、甾体等。药理学研究表明泽泻醇提物、水提物及一些单体类成分具有利尿、抗结石及肾脏保护、降血脂及保肝、降血糖、抗癌、抗氧化损伤、抗炎、抗补体等作用。该文对近五十年来泽泻的化学成分和药理作用进行了全面系统的整理,以期为泽泻的深入研究和开发利用提供理论依据。
Alismatis Rhizoma is a traditional Chinese medicine, which was widely used in clinical prescriptions and proprietary Chinese medicine. Over 220 compounds have been isolated from it, including triterpenoids, sesquiterpenoids, diterpenoids, polysaccharides, nitrogen compounds, phenylpropanoids, flavones and sterides. The pharmacological studies show that Alismatis Rhizoma exhibits diuretic, anti-urolithiatic, anti-hyperlipidemia, antidiabetics, antitumor, antioxidative, anti-inflammatory, anti-complementary activities, etc. In this review, the chemical compositions and its pharmacological activities of Alismatis Rhizoma in recent 50 years were summarized. The authors hope to provide references for further study, development and utilization of Alismatis Rhizoma.

关键词(KeyWords)： 泽泻;化学成分;三萜;倍半萜;药理作用
Alismatis Rhizoma;chemical compositions;triterpenoids;sesquiterpenoids;biological activities

Abstract:

Keywords:

基金项目(Foundation): 国家中药标准化项目(ZYBZH-C-JL-24);; 国家药典委员会标准制修订研究课题(2018Z079)

作者(Authors): 刘珊珊;郭杰;李宗艾;田双双;朱晶晶;闫利华;王智民;高陆;
LIU Shan-shan;GUO Jie;LI Zong-ai;TIAN Shuang-shuang;ZHU Jing-jing;YAN Li-hua;WANG Zhi-min;GAO Lu;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences;Tianjin University of Traditional Chinese Medicine;Xiuzheng Pharmaceutical Group Co., Ltd.;

DOI: 10.19540/j.cnki.cjcmm.20190616.201

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