中国中药杂志

2014, v.39(20) 3905-3909

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麦角甾酮的药理活性、药代动力学及含量测定研究进展
Research progress on pharmacology,pharmacokinetics and determination of ergosta-4,6,8( 14),22-tetraen-3-one

陈晗;陈丹倩;李全福;李鹏飞;陈华;赵英永;
CHEN Han;CHEN Dan-qian;LI Quan-fu;LI Peng-fei;CHEN Hua;ZHAO Ying-yong;Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,the College of Life Sciences,Northwest University;

摘要(Abstract):

麦角甾酮是多种药用真菌的主要化学成分之一,具有利尿、抗肿瘤、免疫抑制、治疗慢性肾脏病等多种生物活性。基于已报道的相关文献,该文综述了麦角甾酮的波谱特征、含量测定、药理活性及药代动力学等研究进展,为深入研究与开发利用麦角甾酮提供一定价值的参考。
Ergosta-4,6,8( 14),22-tetraen-3-one( ergone) is one of main components in many medicinal fungi. Ergone has been reported to possess the activities of diuresis,cytotoxicity,antitumor,immunosuppression,as well as treatment of chronic kidney disease. According to reported literatures,an overview of spectroscopy characteristics,content determination,pharmacological activity and pharmacokinetics,etc. for ergone is presented in this review. Furthermore,the present review can provide a certain reference value for the further study and development of ergone.

关键词(KeyWords): 麦角甾酮;利尿;慢性肾脏病;细胞毒活性;药代动力学;含量测定
ergosta-4,6,8(14),22-tetraen-3-one;diuresis;chronic kidney disease;pharmacokinetics;content determination

Abstract:

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基金项目(Foundation): 教育部“新世纪优秀人才计划”项目(NCET-13-0954);; 长江学者和创新团队发展计划(IRT1174);; 国家自然科学基金项目(J1210063,81202909,81274025);; 陕西省国际合作项目(2013KW31-01);; 国家创新训练计划项目(201310697004)

作者(Author): 陈晗;陈丹倩;李全福;李鹏飞;陈华;赵英永;
CHEN Han;CHEN Dan-qian;LI Quan-fu;LI Peng-fei;CHEN Hua;ZHAO Ying-yong;Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,the College of Life Sciences,Northwest University;

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